百里香酚、香芹酚和丁香酚对微小牛蜱和血红扇头蜱幼虫的协同作用
Synergism of thymol, carvacrol and eugenol in larvae of the cattle tick, Rhipicephalus microplus, and brown dog tick, Rhipicephalus sanguineus.
作者信息
Araújo L X, Novato T P L, Zeringota V, Maturano R, Melo D, DA Silva B C, Daemon E, DE Carvalho M G, Monteiro C M O
机构信息
Programa de Pós-Graduação em Ciências Biológicas, Comportamento e Biologia Animal, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.
Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, Brazil.
出版信息
Med Vet Entomol. 2016 Dec;30(4):377-382. doi: 10.1111/mve.12181. Epub 2016 Jul 9.
The effects of combinations of the monoterpenes thymol and carvacrol and the phenylpropanoid eugenol in larvae of Rhipicephalus microplus (Canestrini, 1888) (Acari: Ixodidae) and Rhipicephalus sanguineus sensu lato (s.l.) (Acari: Ixodidae) were assessed by the larval packet test. The CompuSyn program was used to make qualitative assessments of the effects (synergistic, additive and antagonistic) of the associations. The effects of all combinations tested against R. microplus larvae were synergistic, with combination indices (CIs) <0.70. When tested against R. sanguineus, eight of the mixtures showed a synergistic effect (CI < 0.70); only the carvacrol + thymol mixture at LC presented a moderate synergistic effect, with CIs between 0.70-0.90. This study is the first to determine the effects of the interactions of these substances in the control of these two tick species. The combinations of carvacrol + thymol, carvacrol + eugenol and thymol + eugenol have synergistic effects in R. microplus and R. sanguineus s.l. larvae.
通过幼虫包囊试验评估了单萜类百里香酚和香芹酚以及苯丙烷类丁香酚组合对微小扇头蜱（Canestrini，1888）（蜱螨亚纲：硬蜱科）和血红扇头蜱狭义（蜱螨亚纲：硬蜱科）幼虫的影响。使用CompuSyn程序对这些组合的效果（协同、相加和拮抗）进行定性评估。所有测试组合对微小扇头蜱幼虫的影响均为协同作用，组合指数（CI）<0.70。在对血红扇头蜱进行测试时，八种混合物表现出协同作用（CI < 0.70）；只有在LC浓度下的香芹酚 + 百里香酚混合物呈现出中等协同作用，CI在0.70 - 0.90之间。本研究首次确定了这些物质的相互作用在控制这两种蜱类中的效果。香芹酚 + 百里香酚、香芹酚 + 丁香酚和百里香酚 + 丁香酚的组合在微小扇头蜱和血红扇头蜱狭义幼虫中具有协同作用。
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