意大利野猪中戊型肝炎病毒（HEV）3型c亚型的检测与基因特征分析。
Detection and genetic characterization of hepatitis E virus (HEV) genotype 3 subtype c in wild boars in Italy.
作者信息
Di Profio Federica, Melegari Irene, Sarchese Vittorio, Robetto Serena, Marruchella Giuseppe, Bona Maria Cristina, Orusa Riccardo, Martella Vito, Marsilio Fulvio, Di Martino Barbara
机构信息
Faculty of Veterinary Medicine, Università degli Studi di Teramo, University of Teramo, Piazza Aldo Moro, 45, 64100, Teramo, Italy.
Istituto Zooprofilattico Sperimentale del Piemonte, della Liguria e della Valle d'Aosta, Struttura Complessa Valle d'Aosta con annesso Centro di Referenza Nazionale per le Malattie degli Animali Selvatici (CeRMAS), Torino, Italy.
出版信息
Arch Virol. 2016 Oct;161(10):2829-34. doi: 10.1007/s00705-016-2964-y. Epub 2016 Jul 8.
Hepatitis E virus (HEV) was detected in stools collected from wild boars in Italy, with an overall prevalence of 1.5 % (3/196). The sequence of a ~3.0-kb portion at the 3' end of the genome of one such strain, HEV/WB/P6-15/ITA, was determined. In the full-length ORF2, which encodes the capsid protein, the virus was genetically closest to wild boar and human HEV strains currently classified as genotype 3 subtype c. Interestingly, the 3' end of ORF2 of the WB/P6-15/ITA matched the 340-nucleotide (nt) sequence (94.0 % nt identity) of the human strain PeGe, identified in 2015 from a patient with acute hepatitis E in Genoa, Italy, suggesting that similar HEV strains are circulating in the same geographical setting in humans and animals.
在意大利从野猪粪便中检测到戊型肝炎病毒（HEV），总体患病率为1.5%（3/196）。确定了其中一株病毒HEV/WB/P6-15/ITA基因组3'端约3.0 kb部分的序列。在编码衣壳蛋白的全长ORF2中，该病毒在基因上与目前归类为3型c亚型的野猪和人类HEV毒株最为接近。有趣的是，WB/P6-15/ITA的ORF2 3'端与2015年在意大利热那亚一名急性戊型肝炎患者中鉴定出的人类毒株PeGe的340个核苷酸（nt）序列匹配（nt同一性为94.0%），这表明相似的HEV毒株在人类和动物的同一地理区域传播。
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