van der Stouwe Elisabeth C D, de Vries Bertine, Aleman André, Arends Johan, Waarheid Clement, Meerdink Aniek, van der Helm Erwin, van Busschbach Jooske T, Pijnenborg Gerdina H M
Department of Neuroscience, BCN Neuroimaging Center, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 2, 9713 AW, Groningen, The Netherlands.
University of Groningen, University Medical Center Groningen, University Center of Psychiatry, Rob Giel Onderzoekcentrum, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
BMC Psychiatry. 2016 Jul 8;16:227. doi: 10.1186/s12888-016-0918-2.
Individuals with a psychotic disorder are at an increased risk of becoming victim of a crime or other forms of aggression. Research has revealed several possible risk factors (e.g. impaired social cognition, aggression regulation problems, assertiveness, self-stigma, self-esteem) for victimization in patients with a psychotic disorder. To address these risk factors and prevent victimization, we developed a body-oriented resilience training with elements of kickboxing: BEATVIC. The present study aims to evaluate the effectiveness of the intervention.
METHODS/DESIGN: Seven mental health institutions in the Netherlands will participate in this study. Participants will be randomly assigned to either the BEATVIC training or the control condition: social activation. Follow-ups are at 6, 18 and 30 months. Short term effects on risk factors for victimization will be examined, since these are direct targets of the intervention and are thought to be mediators of victimization, the primary outcome of the intervention. The effect on victimization will be investigated at follow-up. In a subgroup of patients, fMRI scans will be made before and after the intervention period in order to assess potential neural changes associated with the effects of the training.
This study is the first to examine the effectiveness of an intervention targeted at victimization in psychosis. Methodological issues of the study are addressed in the discussion of this paper.
Current Controlled Trials: ISRCTN21423535 . Retrospectively registered 30-03-2016.
患有精神障碍的个体成为犯罪或其他形式攻击行为受害者的风险增加。研究揭示了精神障碍患者受侵害的几种可能风险因素（如社会认知受损、攻击调节问题、自信、自我污名化、自尊）。为解决这些风险因素并预防受侵害情况，我们开发了一种融入跆拳道元素的身体导向复原力训练：BEATVIC。本研究旨在评估该干预措施的有效性。
方法/设计：荷兰的七家心理健康机构将参与本研究。参与者将被随机分配到BEATVIC训练组或对照组：社交激活组。随访时间为6个月、18个月和30个月。将检查对受侵害风险因素的短期影响，因为这些是干预的直接目标，并且被认为是受侵害情况（干预的主要结果）的中介因素。将在随访时调查对受侵害情况的影响。在一组患者中，将在干预期前后进行功能磁共振成像扫描，以评估与训练效果相关的潜在神经变化。
本研究是首次检验针对精神病患者受侵害情况的干预措施的有效性。本文的讨论部分阐述了该研究的方法学问题。
当前受控试验：ISRCTN21423535。于2016年3月30日进行回顾性注册。
