College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 94 Weijin Road, Tianjin 300071, China.
Nat Commun. 2016 Jul 12;7:12104. doi: 10.1038/ncomms12104.
Covalent organic frameworks (COFs) are a novel class of porous materials, and offer great potential for various applications. However, the applications of COFs in chiral separation and chiral catalysis are largely underexplored due to the very limited chiral COFs available and their challenging synthesis. Here we show a bottom-up strategy to construct chiral COFs and an in situ growth approach to fabricate chiral COF-bound capillary columns for chiral gas chromatography. We incorporate the chiral centres into one of the organic ligands for the synthesis of the chiral COFs. We subsequently in situ prepare the COF-bound capillary columns. The prepared chiral COFs and their bound capillary columns give high resolution for the separation of enantiomers with excellent repeatability and reproducibility. The proposed strategy provides a promising platform for the synthesis of chiral COFs and their chiral separation application.
共价有机框架（COFs）是一类新型的多孔材料，具有广泛的应用潜力。然而，由于可用的手性 COFs 非常有限，且其合成具有挑战性，因此 COFs 在手性分离和手性催化中的应用在很大程度上仍未得到探索。在这里，我们展示了一种自下而上的策略来构建手性 COFs，并采用原位生长的方法来制备手性 COF 键合毛细管柱用于手性气相色谱。我们将手性中心引入到其中一个有机配体中，以合成手性 COFs。随后，我们在原位制备 COF 键合的毛细管柱。所制备的手性 COFs 及其键合的毛细管柱在手性异构体的分离中具有高分辨率，且具有出色的重现性和可重复性。该策略为手性 COFs 的合成及其手性分离应用提供了一个有前景的平台。
