Bouhuys A L, Beersma D G, van den Hoofdakker R H
Department of Biological Psychiatry, University Psychiatric Clinic, Groningen, The Netherlands.
Psychiatry Res. 1989 Apr;28(1):47-61. doi: 10.1016/0165-1781(89)90197-2.
Total sleep deprivation (TSD) in depressive patients is known to produce sudden changes in mood, but the factors involved in these mood changes are poorly understood. In this study the role of psychomotor activation was investigated by examining the relationships between baseline measures of activation and subsequent clinical response to TSD. Two methods were used to assess the degree of activation: global judgment (clinical ratings) and direct observation and registration of behavior (ethological methods). Behavioral and global assessments took place 1 day before TSD during a medication-free psychiatric interview. The amount of looking displayed during the interview was negatively correlated with the subsequent clinical response to TSD, while body- and object-touching hand movements showed a positive correlation. During switches from speaking turn and at the start of the patients' speaking turn, responders to TSD showed more hand movements than nonresponders. No relation was found between clinical ratings of the degree of psychomotor activation and the TSD response. Our data suggest that the clinical response to TSD may be predicted and therefore possibly mediated by dimensions of activation. For the detection of these dimensions, behavioral observation appears to be more suitable than global clinical judgment.
已知抑郁患者的完全睡眠剥夺（TSD）会导致情绪突然变化，但这些情绪变化所涉及的因素却鲜为人知。在本研究中，通过检查激活的基线测量值与随后对TSD的临床反应之间的关系，来研究精神运动激活的作用。使用了两种方法来评估激活程度：整体判断（临床评分）和对行为的直接观察与记录（行为学方法）。在无药物治疗的精神科访谈中，于TSD前1天进行行为和整体评估。访谈期间显示的注视量与随后对TSD的临床反应呈负相关，而触摸身体和物体的手部动作则呈正相关。在从一个人说话转换到另一个人说话以及患者开始说话时，对TSD有反应的患者比无反应的患者表现出更多的手部动作。未发现精神运动激活程度的临床评分与TSD反应之间存在关联。我们的数据表明，对TSD的临床反应可能是可预测的，因此可能由激活维度介导。对于这些维度的检测，行为观察似乎比整体临床判断更合适。
