秀丽锦龟中萘啶酸的羟基化和氧化作用
Hydroxylation and oxidation of nalidixic acid in the turtle Pseudemys scripta elegans.
作者信息
Vree T B, Vree J B, Baars A M, Nouws J F, Hekster Y A
机构信息
Department of Clinical Pharmacy, Sint Radboud Hospital, University of Nijmegen, The Netherlands.
出版信息
Vet Q. 1988 Jan;10(1):67-9. doi: 10.1080/01652176.1988.9694149.
PMID:3376413
Abstract
The turtle Pseudemys scripta elegans hydroxylates nalidixic acid into 7-hydroxynalidixic acid; this latter metabolite is oxidised into 7-carboxynalidixic acid. The elimination half-life of nalidixic acid in the turtle is 30 h. No glucuronides of nalidixic- and 7-hydroxynalidixic acid are formed, as they are in man.
摘要
锦龟（Pseudemys scripta elegans）可将萘啶酸羟化生成7-羟基萘啶酸；后一种代谢产物会被氧化为7-羧基萘啶酸。萘啶酸在锦龟体内的消除半衰期为30小时。与在人体内不同，萘啶酸和7-羟基萘啶酸不会形成葡萄糖醛酸苷。
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