Rösler A, Mißbach P, Kaatz F, Kopf D
Katholisches Marienkrankenhaus gGmbH, Alfredstr. 9, 22087, Hamburg, Deutschland.
Antares Apotheke, Albert-Schweitzer-Ring 22, 22045, Hamburg, Deutschland.
Z Gerontol Geriatr. 2018 Jan;51(1):74-80. doi: 10.1007/s00391-016-1102-5. Epub 2016 Jul 15.
Older patients suffer more often from drug-induced complications.
What are the precise recommendations pharmacists can give to geriatricians?
Two pharmacists conducted clinical rounds on 2 geriatric wards over a period of 54 weeks. Protocols of conspicuous medications for geriatric patients were analyzed and suggestions were made.
Particularly frequent were the questionable medical indications for proton pump inhibitors, allopurinol, pregabalin and gabapentin. Adjustment of the dosage of heparin and its analogs to impaired renal function of patients was often lacking. This was also occasionally the case for metformin, some antibiotics and simvastatin. There were several interactions of drug combinations with a high risk for QT prolongation. The inhibition of resorption of bisphosphonates and L‑thyroxin by the simultaneous intake of magnesium and calcium seemed to be probable. Furthermore, it was noticed that for some medications for patients treated by percutaneous endoscopic gastrostomy (PRG) administration by feeding tubes was not possible and combinations of different eye drops which should not be applied simultaneously but at delayed time intervals.
An additional medication-related visit provides an interventional option for avoidance of medication errors.
老年患者更容易出现药物引起的并发症。
药剂师能给老年病医生提供哪些确切的建议?
两名药剂师在54周的时间里对两个老年病房进行了临床查房。分析了老年患者显著用药的方案并提出了建议。
质子泵抑制剂、别嘌醇、普瑞巴林和加巴喷丁的可疑医学适应症尤为常见。经常缺乏根据患者肾功能受损情况调整肝素及其类似物剂量的情况。二甲双胍、一些抗生素和辛伐他汀偶尔也会出现这种情况。有几种药物组合存在高风险的QT间期延长相互作用。同时摄入镁和钙似乎可能抑制双膦酸盐和左甲状腺素的吸收。此外,还注意到对于一些经皮内镜下胃造口术(PRG)治疗的患者,通过喂食管给药是不可能的,以及不同眼药水的组合不应同时使用,而应间隔一段时间使用。
额外的药物相关查房为避免用药错误提供了一种干预选择。