Valluru Keerthi S, Wilson Katheryne E, Willmann Jürgen K
From the Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, 300 Pasteur Dr, Room H1307, Stanford, CA 94305-5621.
Radiology. 2016 Aug;280(2):332-49. doi: 10.1148/radiol.16151414.
Photoacoustic imaging has evolved into a clinically translatable platform with the potential to complement existing imaging techniques for the management of cancer, including detection, characterization, prognosis, and treatment monitoring. In photoacoustic imaging, tissue is optically excited to produce ultrasonographic images that represent a spatial map of optical absorption of endogenous constituents such as hemoglobin, fat, melanin, and water or exogenous contrast agents such as dyes and nanoparticles. It can therefore provide functional and molecular information that allows noninvasive soft-tissue characterization. Photoacoustic imaging has matured over the years and is currently being translated into the clinic with various clinical studies underway. In this review, the current state of photoacoustic imaging is presented, including techniques and instrumentation, followed by a discussion of potential clinical applications of this technique for the detection and management of cancer. (©) RSNA, 2016.
光声成像已发展成为一个具有临床可转化性的平台，有潜力补充现有的癌症管理成像技术，包括检测、特征描述、预后评估和治疗监测。在光声成像中，组织受到光激发以产生超声图像，这些图像代表内源性成分（如血红蛋白、脂肪、黑色素和水）或外源性造影剂（如染料和纳米颗粒）的光吸收空间图。因此，它可以提供功能性和分子信息，实现无创软组织特征描述。多年来光声成像已经成熟，目前正在通过各种正在进行的临床研究转化应用于临床。在本综述中，介绍了光声成像的当前状态，包括技术和仪器设备，随后讨论了该技术在癌症检测和管理中的潜在临床应用。(©) RSNA, 2016。
