在涉及跨性别者的艾滋病毒预防试验设计中需考虑的伦理问题。
Ethical Issues to Consider in the Design of HIV Prevention Trials Involving Transgender People.
作者信息
Singh Jerome Amir
机构信息
Center for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R. Mandela School of Medicine, Durban, South Africa.
出版信息
J Acquir Immune Defic Syndr. 2016 Aug 15;72 Suppl 3(Suppl 3):S252-5. doi: 10.1097/QAI.0000000000001089.
Abstract
Although transgender women have been included in HIV prevention pre-exposure prophylaxis studies, no pre-exposure prophylaxis study has focused exclusively on transgender persons. Drawing on the cardinal principles of ethics espoused in the Belmont Report, this work highlights, among other issues, that (1) the principle of Justice requires the HIV prevention field to focus exclusively on transgender persons, (2) the disclosure of potential study-related risks to study participants demonstrates Respect for Persons, and (3) devising risk mitigation plans, optimizing a proposed study's standard of care, and the provision of ancillary care satisfy the principle of Beneficence.
摘要
虽然跨性别女性已被纳入艾滋病病毒预防暴露前预防研究，但尚无专门针对跨性别者的暴露前预防研究。借鉴《贝尔蒙报告》中所倡导的核心伦理原则，这项工作除其他问题外还强调：（1）公正原则要求艾滋病病毒预防领域专门关注跨性别者；（2）向研究参与者披露潜在的研究相关风险体现了对人的尊重；（3）制定风险缓解计划、优化拟议研究的护理标准以及提供辅助护理符合 beneficence 原则。 （注：这里“Beneficence”常见释义为“善行”“慈善”，结合语境可理解为“有益”之类的意思，但可能需根据更具体的医学伦理背景来准确把握其含义。）
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