HM CINAC, Hospital Universitario HM Puerta del Sur, Móstoles, Madrid, Spain.
Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Mov Disord. 2016 Sep;31(9):1283-92. doi: 10.1002/mds.26723. Epub 2016 Jul 19.
The past decade has witnessed a highly dynamic and growing expansion of novel methods aimed at improving the assessment of Parkinson's disease with technology (NAM-PD) in laboratory, clinical, and home environments. However, the current state of NAM-PD regarding their maturity, feasibility, and usefulness in assessing the main PD features has not been systematically evaluated.
A systematic review of articles published in the field from 2005 to 2015 was performed. Of 9,503 publications identified in PubMed and the Web of Science, 848 full papers were evaluated, and 588 original articles were assessed to evaluate the technological, demographic, clinimetric, and technology transfer readiness parameters of NAM-PD.
Of the studies, 65% included fewer than 30 patients, < 50% employed a standard methodology to validate diagnostic tests, 8% confirmed their results in a different dataset, and 87% occurred in a clinic or lab. The axial features domain was the most frequently studied, followed by bradykinesia. Rigidity and nonmotor domains were rarely investigated. Only 6% of the systems reached a technology level that justified the hope of being included in clinical assessments in a useful time period.
This systematic evaluation provides an overview of the current options for quantitative assessment of PD and what can be expected in the near future. There is a particular need for standardized and collaborative studies to confirm the results of preliminary initiatives, assess domains that are currently underinvestigated, and better validate the existing and upcoming NAM-PD. © 2016 International Parkinson and Movement Disorder Society.
过去十年见证了旨在利用技术（NAM-PD）改善实验室、临床和家庭环境中帕金森病评估的新方法的高度动态和不断增长的扩展。然而，目前尚未系统评估 NAM-PD 针对其成熟度、可行性和在评估主要 PD 特征方面的有用性。
对 2005 年至 2015 年在该领域发表的文章进行了系统评价。在 PubMed 和 Web of Science 中确定了 9503 篇出版物，评估了 848 篇全文，并评估了 588 篇原始文章，以评估 NAM-PD 的技术、人口统计学、临床计量学和技术转移准备参数。
在这些研究中，65%的研究纳入的患者少于 30 名，<50%的研究采用标准方法验证诊断测试，8%的研究在不同数据集确认了结果，87%的研究在诊所或实验室进行。轴性特征域是研究最多的，其次是运动迟缓。僵硬和非运动域很少被研究。只有 6%的系统达到了技术水平，有理由在有用的时间内将其纳入临床评估。
本系统评价提供了定量评估 PD 的当前选项概述以及在不久的将来可以预期的情况。特别需要标准化和协作研究来确认初步举措的结果，评估目前研究不足的领域，并更好地验证现有的和即将出现的 NAM-PD。© 2016 国际帕金森病和运动障碍协会。
