Arens Ann M, Anaebere Tiffany C, Horng Howard, Olson Kent
a Department of Emergency Medicine , University of California , San Francisco , CA , USA.
b San Francisco Division , California Poison Control System , San Francisco , CA , USA.
Clin Toxicol (Phila). 2016 Nov;54(9):878-880. doi: 10.1080/15563650.2016.1209765. Epub 2016 Jul 20.
Common yew (Taxus baccata) is a common decorative evergreen shrub with potentially fatal toxicity hallmarked by seizure, arrhythmia and cardiovascular collapse if ingested. Taxine B has been identified as one of the most cardiotoxic taxine alkaloids in Taxus spp, and another alkaloid, 3,5-dimethoxyphenol (3,5-DMP), is used as a marker of ingestion. We present a fatal case of ingestion of yew with perimortem serum and gastric taxine B, and 3,5-DMP concentrations.
A 22-year-old woman was brought to the emergency department (ED) from a nearby botanical garden after she was found apneic and pulseless after a witnessed generalized tonic clonic seizure. The patient was found to have a wide complex rhythm with persistent cardiovascular collapse and expired despite maximal supportive care in the ED. A baggie of plant material was found on the patient, identified as Taxus baccata. Perimortem serum and gastric samples were analyzed to quantify serum and gastric taxine B and 3,5-DMP concentrations.
Perimortem serum showed a 3,5-DMP concentration of 86.9 ng/mL, and taxine B of 80.9 ug/mL.
We report a perimortem serum and gastric taxine B and 3,5-DMP concentrations in a fatal case of T. baccata toxicity.
欧洲红豆杉是一种常见的观赏性常绿灌木，若被误食具有潜在致命毒性，其特征为癫痫发作、心律失常和心血管衰竭。紫杉碱B已被确定为红豆杉属中最具心脏毒性的紫杉碱生物碱之一，另一种生物碱3,5-二甲氧基苯酚（3,5-DMP）被用作摄入的标志物。我们报告一例欧洲红豆杉中毒致死病例，其中包括死后血清和胃中紫杉碱B以及3,5-DMP的浓度。
一名22岁女性在目睹全身性强直阵挛性癫痫发作后出现呼吸暂停和脉搏消失，随后从附近植物园被送往急诊科（ED）。该患者被发现有宽QRS波心律，伴有持续性心血管衰竭，尽管在急诊科接受了最大程度的支持治疗仍死亡。在患者身上发现一袋植物材料，经鉴定为欧洲红豆杉。对死后血清和胃样本进行分析，以量化血清和胃中紫杉碱B以及3,5-DMP的浓度。
死后血清显示3,5-DMP浓度为86.9 ng/mL，紫杉碱B浓度为80.9 μg/mL。
我们报告了一例欧洲红豆杉中毒致死病例的死后血清和胃中紫杉碱B以及3,5-DMP的浓度。
