Meillet D, Labrousse F, Benoit M O, Hernvann A, Musset L, van Amerongen G
Hôpital de la Salpêtrière, Paris, France.
Eur J Clin Chem Clin Biochem. 1997 Apr;35(4):275-9. doi: 10.1515/cclm.1997.35.4.275.
Enhanced serum IgA concentrations are common in alcoholic liver cirrhosis, but functional differences between IgA subclasses and their relation with interleukin-6 (IL-6) have not been described. Distinct immunoregulatory mechanisms may exist that selectively affect one subclass. This possibility prompted us to investigate the distribution of IgA1 and IgA2 subclasses in the serum of 25 heavy alcohol drinkers (alcohol: 80 to 200 g per day) without clinical disorders, in comparison with 35 patients affected by alcoholic liver cirrhosis, 29 viral hepatitis patients and 33 social drinkers as a control group. Mean (+/- SD) IgA2 concentration (0.56 +/- 0.31 g/l) was significantly increased (p < 0.01) in heavy alcohol drinkers, with an IgA2/IgA1 ratio of 0.33 +/- 0.12, while the mean total IgA concentration was similar to the control group. Mean IgA1 and IgA2 concentrations were significantly increased (p < 0.001) in alcoholic liver cirrhosis patients (6.13 +/- 4.52 g/l and 1.83 +/- 1.93 g/l respectively, with an IgA2/IgA1 ratio of 0.32 +/- 0.19) and viral hepatitis patients (3.66 +/- 2.59 g/l and 0.69 +/- 0.67 g/l respectively, with an IgA2/IgA1 ratio of 0.21 +/- 0.14) High serum IL-6 concentrations (34 +/- 33 ng/l) were correlated with elevated IgA1 and IgA2 concentrations only in patients with alcoholic liver cirrhosis. IgA2 subclass and IgA2/IgA1 ratio could therefore be used as markers of chronic alcohol abuse directly related to the extent and duration of the alcohol abuse and the effectiveness of alcohol withdrawal.
血清IgA浓度升高在酒精性肝硬化中很常见，但IgA亚类之间的功能差异及其与白细胞介素-6（IL-6）的关系尚未见描述。可能存在不同的免疫调节机制，可选择性地影响一个亚类。这种可能性促使我们研究25名无临床疾病的重度饮酒者（酒精摄入量：每天80至200克）血清中IgA1和IgA2亚类的分布情况，并与35名酒精性肝硬化患者、29名病毒性肝炎患者以及33名社会饮酒者作为对照组进行比较。重度饮酒者的平均（±标准差）IgA2浓度（0.56±0.31克/升）显著升高（p<0.01），IgA2/IgA1比值为0.33±0.12，而平均总IgA浓度与对照组相似。酒精性肝硬化患者（分别为6.13±4.52克/升和1.83±1.93克/升，IgA2/IgA1比值为0.32±0.19）和病毒性肝炎患者（分别为3.66±2.59克/升和0.69±0.67克/升，IgA2/IgA1比值为0.21±0.14）的平均IgA1和IgA2浓度显著升高（p<0.001）。高血清IL-6浓度（34±33纳克/升）仅在酒精性肝硬化患者中与升高的IgA1和IgA2浓度相关。因此，IgA2亚类和IgA2/IgA1比值可作为慢性酒精滥用的标志物，直接与酒精滥用的程度和持续时间以及戒酒的效果相关。
