Mifflin Katherine A, Kerr Bradley J
Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.
J Neurosci Res. 2017 Jun;95(6):1282-1294. doi: 10.1002/jnr.23844. Epub 2016 Jul 22.
Most autoimmune diseases are associated with pathological pain development. Autoimmune diseases with pathological pain include complex regional pain syndrome, rheumatoid arthritis, and Guillian-Barré syndrome to name a few. The present Review explores research linking the immune system to the development of pathological pain in autoimmune diseases. Pathological pain has been linked to T-cell activation and the release of cytokines from activated microglia in the dorsal horn of the spinal cord. New research on the role of autoantibodies in autoimmunity has generated insights into potential mechanisms of pain associated with autoimmune disease. Autoantibodies may act through various mechanisms in autoimmune disorders. These include the alteration of neuronal excitability via specific antigens such as the voltage-gated potassium channel complexes or by mediating bone destruction in rheumatoid arthritis. Although more research must be done to understand better the role of autoantibodies in autoimmune disease related pain, this may be a promising area of research for new analgesic therapeutic targets. © 2016 Wiley Periodicals, Inc.
大多数自身免疫性疾病都与病理性疼痛的发展有关。伴有病理性疼痛的自身免疫性疾病包括复杂性区域疼痛综合征、类风湿性关节炎和格林-巴利综合征等。本综述探讨了将免疫系统与自身免疫性疾病中病理性疼痛发展相联系的研究。病理性疼痛与T细胞活化以及脊髓背角中活化的小胶质细胞释放细胞因子有关。关于自身抗体在自身免疫中作用的新研究为与自身免疫性疾病相关的疼痛潜在机制提供了见解。自身抗体可能通过多种机制在自身免疫性疾病中发挥作用。这些机制包括通过特定抗原（如电压门控钾通道复合物）改变神经元兴奋性，或在类风湿性关节炎中介导骨质破坏。尽管还需要开展更多研究以更好地了解自身抗体在自身免疫性疾病相关疼痛中的作用，但这可能是一个有前景的新镇痛治疗靶点研究领域。© 2016威利期刊公司
