Remya N S, Syama S, Sabareeswaran A, Mohanan P V
Toxicology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Trivandrum 695 012, Kerala, India.
Toxicology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Trivandrum 695 012, Kerala, India.
Int J Pharm. 2016 Sep 10;511(1):586-598. doi: 10.1016/j.ijpharm.2016.06.119. Epub 2016 Jul 20.
Advancement in the field of nanoscience and technology has alarmingly raised the call for comprehending the potential health effects caused by deliberate or unintentional exposure to nanoparticles. Iron oxide magnetic nanoparticles have an increasing number of biomedical applications and hence a complete toxicological profile of the nanomaterial is therefore a mandatory requirement prior to its intended usage to ensure safety and to minimize potential health hazards upon its exposure. The present study elucidates the toxicity of in house synthesized Dextran stabilized iron oxide nanoparticles (DINP) in a regulatory perspective through various routes of exposure, its associated molecular, immune, genotoxic, carcinogenic effects and bio distribution profile. Synthesized ferrite nanomaterials were successfully coated with dextran (<25nm) and were physicochemically characterized and subjected to in vitro and in vivo toxicity evaluations. The results suggest that surface coating of ferrite nanoparticles with dextran helps in improvising particle stability in biological environments. The nanoparticles do not seem to induce oxidative stress mediated toxicological effects, nor altered physiological process or behavior changes or visible pathological lesions. Furthermore no anticipated health hazards are likely to be associated with the use of DINP and could be concluded that the synthesized DINP is nontoxic/safe to be used for biomedical applications.
纳米科学与技术领域的进展令人担忧地引发了人们对于理解有意或无意接触纳米颗粒所导致的潜在健康影响的呼声。氧化铁磁性纳米颗粒在生物医学领域的应用日益增多，因此，在纳米材料用于预期用途之前，全面了解其毒理学特征是确保安全并将其暴露时的潜在健康危害降至最低的一项强制性要求。本研究从监管角度阐明了实验室合成的葡聚糖稳定化氧化铁纳米颗粒（DINP）通过各种暴露途径所产生的毒性、其相关的分子、免疫、遗传毒性、致癌作用及生物分布情况。合成的铁氧体纳米材料成功地用葡聚糖（<25nm）进行了包覆，并对其进行了物理化学表征以及体外和体内毒性评估。结果表明，用葡聚糖对铁氧体纳米颗粒进行表面包覆有助于提高其在生物环境中的颗粒稳定性。这些纳米颗粒似乎不会诱导氧化应激介导的毒理学效应，也不会改变生理过程、行为或产生可见的病理损伤。此外，使用DINP不太可能会带来预期的健康危害，可以得出结论，合成的DINP无毒/可安全用于生物医学应用。
