Lima A G C F, Santos V S, Nunes M S, Barreto J A A, Ribeiro C J N, Carvalho J, Ribeiro M C O
Postgraduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Brazil.
Department of Nursing, Federal University of Sergipe, Lagarto, Brazil.
Eur J Pain. 2017 Jan;21(1):159-165. doi: 10.1002/ejp.912. Epub 2016 Jul 26.
Few studies have compared the analgesic effect of 25% glucose and non-nutritive sucking. We compared the analgesic effect of 25% glucose and non-nutritive sucking in newborns undergoing hepatitis B vaccination. Our hypothesis is that 25% glucose is more effective in relieving pain than non-nutritive sucking.
A randomized clinical trial with 78 healthy newborns was performed. Neonates were assigned randomly to receive 25% glucose (G25) and non-nutritive sucking (NNS). Pain was assessed using the Neonatal Infant Pain Scale (NIPS) before and during the immunization procedure. In addition, we evaluated various physiological parameters and crying time.
Neonates who received 25% glucose registered lower NIPS scores than those from the NNS group [mean (SD), 3.3 (2.1) vs. 5.6 (1.6), p < 0.001]. The crying time was shorter among newborns in the G25 group than in the NNS and control groups.
The use of 25% glucose before the vaccination procedure was more effective in relieving acute pain, with newborns in the G25 group registering scores two times lower on the NIPS scale. The clinical practice of administering 25% glucose is therefore a suggested nondrug measure for pain relief during painful procedures.
Neonates who received 25% glucose registered lower NIPS scores than those from the NNS group; the crying time was shorter among newborns in the G25 group than in the NNS and control groups; the use of 25% glucose before the vaccination procedure was more effective in relieving acute pain.
很少有研究比较25%葡萄糖溶液和非营养性吸吮的镇痛效果。我们比较了25%葡萄糖溶液和非营养性吸吮对接受乙型肝炎疫苗接种新生儿的镇痛效果。我们的假设是，25%葡萄糖溶液在缓解疼痛方面比非营养性吸吮更有效。
对78名健康新生儿进行了一项随机临床试验。新生儿被随机分配接受25%葡萄糖溶液（G25）和非营养性吸吮（NNS）。在免疫接种过程之前和期间，使用新生儿婴儿疼痛量表（NIPS）评估疼痛。此外，我们还评估了各种生理参数和哭闹时间。
接受25%葡萄糖溶液的新生儿NIPS评分低于非营养性吸吮组[平均值（标准差），3.3（2.1）对5.6（1.6），p<0.001]。G25组新生儿的哭闹时间比非营养性吸吮组和对照组短。
接种疫苗前使用25%葡萄糖溶液在缓解急性疼痛方面更有效，G25组新生儿在NIPS量表上的得分低两倍。因此，给予25%葡萄糖溶液的临床实践是一种建议的在痛苦操作期间缓解疼痛的非药物措施。
接受25%葡萄糖溶液的新生儿NIPS评分低于非营养性吸吮组；G25组新生儿的哭闹时间比非营养性吸吮组和对照组短；接种疫苗前使用25%葡萄糖溶液在缓解急性疼痛方面更有效。
