Reimers C D, Pongratz D E, Neubert U, Pilz A, Hübner G, Naegele M, Wilske B, Duray P H, de Koning J
Friedrich Baur Institute, Clinic for Internal Medicine Innenstadt, F.R.G.
J Neurol Sci. 1989 Jun;91(1-2):215-26. doi: 10.1016/0022-510x(89)90089-0.
Myositis was proven histopathologically in 4 patients (age range 36-66 years) who suffered from early or late stages of Borrelia burgdorferi infection. Muscle weakness was present in 3 patients, 1 complaining of additional myalgias. One man came to medical attention because of skin discoloration and swelling of one leg. Deep biopsy from skin, fascia and muscle revealed acrodermatitis chronica atrophicans, panniculitis, fasciitis, and myositis, respectively. Creatine kinase was slightly elevated in 3 cases and normal in one. Infiltrates were found in the perimysium and within the muscle bundles, mainly around small vessels. The infiltrates consisted of many B cells and T4 lymphocytes with fewer cytotoxic T cells, suggesting that Borrelia myositis might be due to a local immune response to unknown Borrelia antigens. Cultivation of Borrelia from muscle was not successful. Antibiotic therapy cured the myositis.
4例（年龄范围36 - 66岁）患有早期或晚期伯氏疏螺旋体感染的患者经组织病理学证实患有肌炎。3例患者存在肌肉无力，1例还主诉有肌痛。1名男性因一条腿皮肤变色和肿胀前来就医。皮肤、筋膜和肌肉的深部活检分别显示为慢性萎缩性肢端皮炎、脂膜炎、筋膜炎和肌炎。3例患者的肌酸激酶轻度升高，1例正常。在肌束膜和肌束内发现浸润，主要围绕小血管。浸润物由许多B细胞和T4淋巴细胞组成，细胞毒性T细胞较少，提示伯氏疏螺旋体肌炎可能是对未知伯氏疏螺旋体抗原的局部免疫反应所致。从肌肉中培养出伯氏疏螺旋体未获成功。抗生素治疗治愈了肌炎。
