Rapaport Mark Hyman, Schettler Pamela, Larson Erika R, Edwards Sherry A, Dunlop Boadie W, Rakofsky Jeffrey J, Kinkead Becky
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 2nd Fl, 12 Executive Park Dr NE, Atlanta, GA 30329.
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
J Clin Psychiatry. 2016 Jul;77(7):e883-91. doi: 10.4088/JCP.15m10151.
Generalized anxiety disorder (GAD) is a prevalent and costly disorder for which many patients may prefer nontraditional treatment. A proof-of-concept study of was conducted to evaluate the acute effects of Swedish massage therapy (SMT) as a monotherapy for the treatment of subjects with GAD.
A randomized, single-masked, clinical trial was conducted between March 2012 and May 2013 at the Mood and Anxiety Disorders Program of Emory University. Forty-seven currently untreated subjects with a DSM-IV diagnosis of GAD were randomly assigned to twice-weekly SMT versus a light touch control condition for 6 weeks. The primary outcome measure was reduction in Hamilton Anxiety Rating Scale (HARS) scores after 6 weeks of treatment for SMT versus light touch, as determined by mixed model repeated-measures analysis of 40 evaluable subjects.
Mean HARS baseline scores were 20.05 (SD = 3.34) for SMT and 19.58 (SD = 4.90) for light touch. At week 6, the difference in mean (standard error of the mean [SEM]) HARS score reduction was 3.26 points (SMT: -11.67 [1.09]; light touch: -8.41 [1.01]; t₁₀₆ = -2.19; P = .030; effect size = -0.69). Treatment group differences were significant (P < .05) starting at the end of week 3.
This first monotherapy trial suggests that a complementary and alternative manual therapy, SMT, is an effective acute treatment for GAD.
ClinicalTrials.gov identifier: NCT01337713.
广泛性焦虑症（GAD）是一种常见且代价高昂的疾病，许多患者可能更倾向于非传统治疗方法。本研究进行了一项概念验证性研究，以评估瑞典式按摩疗法（SMT）作为治疗GAD患者的单一疗法的急性疗效。
2012年3月至2013年5月在埃默里大学情绪与焦虑症项目组进行了一项随机、单盲临床试验。47名目前未接受治疗且符合《精神疾病诊断与统计手册》第四版（DSM-IV）中GAD诊断标准的受试者被随机分配，分别接受每周两次的SMT治疗或轻触对照治疗，为期6周。主要结局指标是通过对40名可评估受试者进行混合模型重复测量分析，比较SMT组与轻触组在治疗6周后汉密尔顿焦虑量表（HARS）评分的降低情况。
SMT组的HARS基线平均评分为20.05（标准差 = 3.34），轻触组为19.58（标准差 = 4.90）。在第6周时，HARS评分降低的平均（平均标准误[SEM]）差异为3.26分（SMT组：-11.67 [1.09]；轻触组：-8.41 [1.01]；t₁₀₆ = -2.19；P = 0.030；效应量 = -0.69）。从第3周结束时起治疗组差异显著（P < 0.05）。
这项首个单一疗法试验表明，一种补充替代手法治疗——SMT，是治疗GAD的一种有效的急性治疗方法。
ClinicalTrials.gov标识符：NCT01337713。
