Wei J, Lau S Y, Blenkiron C, Chen Q, James J L, Kleffmann T, Wise M, Stone P R, Chamley L W
Department of Obstetrics and Gynaecology, The University of Auckland, New Zealand.
Department of Surgery, The University of Auckland, New Zealand.
Sci Rep. 2016 Jul 29;6:30632. doi: 10.1038/srep30632.
The mechanisms by which the fetus induces maternal physiological adaptations to pregnancy are unclear. Cellular debris, shed from the placental syncytiotrophoblast into the maternal blood and phagocytosed by maternal endothelial and immune cells, may be one of these mechanisms. Here we show that trophoblastic debris from normal first trimester placentae induces changes in the transcriptome and proteome of endothelial cells in vitro, which might contribute to the adaptation of the maternal cardiovascular system to pregnancy. Trophoblastic debris also induced endothelial cells to transcribe placenta-specific genes, including the vasodilator hormone CSH1, thereby expanding the effective functional size of the placenta. Our data suggest that the deportation of trophoblastic debris is an important part of the complex network of feto-maternal communication.
胎儿诱导母体产生妊娠生理适应性变化的机制尚不清楚。从胎盘合体滋养层脱落至母体血液并被母体内皮细胞和免疫细胞吞噬的细胞碎片可能是其中一种机制。在此我们表明，来自正常孕早期胎盘的滋养层碎片在体外可诱导内皮细胞转录组和蛋白质组发生变化，这可能有助于母体心血管系统适应妊娠。滋养层碎片还诱导内皮细胞转录胎盘特异性基因，包括血管舒张激素CSH1，从而扩大胎盘的有效功能面积。我们的数据表明，滋养层碎片的排出是母胎通讯复杂网络的重要组成部分。
