Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2 Suppl 1):155-60.
Periodontitis is a multifactorial disease that, if untreated, may cause teeth loss. Clinicians and researchers have reported that genetic factors influence the clinical manifestations of periodontal disease (PD), modulating both inflammation of the mucous membranes and loss of alveolar bone. The acquisition of new nowledge about genetic susceptibility of PD, would directly impact on prognosis and treatment of the disease. In addition, a better understanding of PD pathogenesis could improve the diagnostic tools for the prevention and therapies for modulation of immune responses and treatment of PD. In this study, we evaluated genetic polymorphisms of VRD, IL6 and IL10 and amounts of periodontal pathogens in Italian adults affected by PD. We included 326 cases classified according the criteria of the American Academy of Periodontology. No significant differences in bacterial load were found in patients carrying PD susceptibility alleles of IL6, IL10 and VDR genes. In conclusion, no interaction between genetic factors and amount of periodontal pathogens in periodontal pockets were found in PD patients.
牙周炎是一种多因素疾病，如果不治疗，可能会导致牙齿脱落。临床医生和研究人员报告称，遗传因素影响牙周病（PD）的临床表现，调节黏膜炎症和牙槽骨丧失。对 PD 遗传易感性的新知识的获取将直接影响疾病的预后和治疗。此外，对 PD 发病机制的更好理解可以改善预防和调节免疫反应以及治疗 PD 的诊断工具。在这项研究中，我们评估了意大利 PD 患者的 VRD、IL6 和 IL10 基因多态性和牙周病病原体的数量。我们纳入了根据美国牙周病学会标准分类的 326 例病例。在携带 IL6、IL10 和 VDR 基因 PD 易感等位基因的患者中，细菌负荷没有差异。总之，在 PD 患者中，没有发现遗传因素与牙周袋中牙周病病原体数量之间的相互作用。
