Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419840844. doi: 10.1177/2058738419840844.
In recent decades, the role played by the immune response to bacteria in the pathogenesis of chronic periodontal disease (PD) has long been studied. Although from the clinical point of view, adequate oral hygiene is essential to ensure a satisfactory response of the host to infections, modulation of the reaction of immune system could be influenced by genetic factors. The aim of the present study was to investigate the distribution of alleles of polymorphisms relevant for chronic periodontitis in a sample of adult subjects affected by chronic PD. The present study was conducted with sample collected in Italian private practice offices from January 2013 to December 2017. The sample included 744 adult patients diagnosed with chronic periodontitis. The inclusion criteria were as follows: age > 18 years, diagnosis of chronic PD. The diagnosis of chronic periodontitis was based on the criteria established by the American Academy of Periodontology. No significant difference in allele distribution among patients from different Italian regions was found. Results, supporting absence of population heterogeneity for the investigated polymorphisms in Italy, suggest similar effect in periodontitis etiology.
近几十年来，人们长期研究了细菌免疫应答在慢性牙周病（PD）发病机制中的作用。尽管从临床角度来看，充分的口腔卫生对于确保宿主对感染的满意反应至关重要，但免疫系统反应的调节可能受到遗传因素的影响。本研究旨在调查与慢性牙周炎相关的多态性等位基因在受慢性 PD 影响的成年患者样本中的分布。本研究于 2013 年 1 月至 2017 年 12 月在意大利私人诊所收集样本进行。该样本包括 744 名被诊断为慢性牙周炎的成年患者。纳入标准如下：年龄>18 岁，诊断为慢性 PD。慢性牙周炎的诊断基于牙周病学美国学院制定的标准。来自意大利不同地区的患者的等位基因分布无显著差异。结果支持意大利对所研究多态性无群体异质性，提示其在牙周炎病因学中具有相似作用。
