• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

天然和合成交联试剂对壳聚糖基杂化水凝胶结构和力学性能的影响。

Influence of natural and synthetic crosslinking reagents on the structural and mechanical properties of chitosan-based hybrid hydrogels.

机构信息

Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Apdo. Postal 70-360, Cd. Universitaria, Cd. de México 04530, Mexico; Posgrado en Ciencia e Ingeniería de Materiales, Universidad Nacional Autónoma de México, Apdo, Postal 70-360, Cd. Universitaria, Cd. de México 04530, Mexico.

Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Apdo. Postal 70-360, Cd. Universitaria, Cd. de México 04530, Mexico.

出版信息

Carbohydr Polym. 2016 Oct 20;151:1073-1081. doi: 10.1016/j.carbpol.2016.06.036. Epub 2016 Jun 17.

DOI:10.1016/j.carbpol.2016.06.036
PMID:27474657
Abstract

The objective of this work was to correlate the physical and chemical properties of chitosan/poly(vinyl alcohol)/genipin (CS/PVA/GEN) and chitosan/poly(vinyl alcohol)/glutaraldehyde (CS/PVA/GA) hydrogels with their structural and mechanical responses. In addition, their molecular structures were determined and confirmed using FTIR spectroscopy. The results indicated that the hybrid hydrogels crosslinked with genipin showed similar crystallinity, thermal properties, elongation ratio and structural parameters as those crosslinked with glutaraldehyde. However, it was found that the elastic moduli of the two hybrid hydrogels were slightly different: 2.82±0.33MPa and 2.08±0.11MPa for GA and GEN, respectively. Although the hybrid hydrogels crosslinked with GEN presented a lower elastic modulus, the main advantage is that GEN is five to ten thousand times less cytotoxic than GA. This means that the structural and mechanical properties of hybrid hydrogels crosslinked with GEN can easily be tuned and could have potential applications in the tissue engineering, regenerative medicine, food, agriculture and environmental industries.

摘要

本工作旨在研究壳聚糖/聚乙烯醇/京尼平（CS/PVA/GEN）和壳聚糖/聚乙烯醇/戊二醛（CS/PVA/GA）水凝胶的物理化学性质与其结构和机械响应之间的相关性。此外，还使用傅里叶变换红外光谱法（FTIR）确定并证实了其分子结构。结果表明，用京尼平交联的杂化水凝胶的结晶度、热性能、伸长率和结构参数与用戊二醛交联的水凝胶相似。然而，发现两种杂化水凝胶的弹性模量略有不同：GA 和 GEN 的弹性模量分别为 2.82±0.33MPa 和 2.08±0.11MPa。尽管用 GEN 交联的杂化水凝胶的弹性模量较低，但主要优点是 GEN 的细胞毒性比 GA 低五到一万倍。这意味着用 GEN 交联的杂化水凝胶的结构和机械性能可以轻松调节，并可能在组织工程、再生医学、食品、农业和环境行业中有潜在应用。

相似文献

1
Influence of natural and synthetic crosslinking reagents on the structural and mechanical properties of chitosan-based hybrid hydrogels.天然和合成交联试剂对壳聚糖基杂化水凝胶结构和力学性能的影响。
Carbohydr Polym. 2016 Oct 20;151:1073-1081. doi: 10.1016/j.carbpol.2016.06.036. Epub 2016 Jun 17.
2
Influence of multi-walled carbon nanotubes on the physico-chemical and biological responses of chitosan-based hybrid hydrogels.多壁碳纳米管对壳聚糖基杂化水凝胶的物理化学和生物学响应的影响。
Carbohydr Polym. 2020 May 15;236:115971. doi: 10.1016/j.carbpol.2020.115971. Epub 2020 Feb 10.
3
Mechanical and structural response of a hybrid hydrogel based on chitosan and poly(vinyl alcohol) cross-linked with epichlorohydrin for potential use in tissue engineering.壳聚糖和聚（乙烯醇）与表氯醇交联的混合水凝胶的机械和结构响应，潜在用于组织工程。
J Biomater Sci Polym Ed. 2014;25(1):32-50. doi: 10.1080/09205063.2013.833441. Epub 2013 Sep 5.
4
Biocompatibility of nanostructured chitosan/ poly(vinyl alcohol) blends chemically crosslinked with genipin for biomedical applications.用于生物医学应用的经京尼平化学交联的纳米结构壳聚糖/聚乙烯醇共混物的生物相容性。
J Biomed Nanotechnol. 2010 Apr;6(2):166-75. doi: 10.1166/jbn.2010.1110.
5
Evaluation of selected properties of biocompatible chitosan/poly(vinyl alcohol) blends.生物相容性壳聚糖/聚乙烯醇共混物选定性能的评估
Int J Biol Macromol. 2016 Jan;82:551-6. doi: 10.1016/j.ijbiomac.2015.09.073. Epub 2015 Oct 3.
6
Triethyl orthoformate mediated a novel crosslinking method for the preparation of hydrogels for tissue engineering applications: characterization and in vitro cytocompatibility analysis.原甲酸三乙酯介导了一种用于制备组织工程应用水凝胶的新型交联方法：表征及体外细胞相容性分析。
Mater Sci Eng C Mater Biol Appl. 2015 Nov 1;56:154-64. doi: 10.1016/j.msec.2015.06.021. Epub 2015 Jun 14.
7
Preparation of 3D Printed Chitosan/Polyvinyl Alcohol Double Network Hydrogel Scaffolds.3D 打印壳聚糖/聚乙烯醇双网络水凝胶支架的制备。
Macromol Biosci. 2021 Apr;21(4):e2000398. doi: 10.1002/mabi.202000398. Epub 2021 Feb 24.
8
Novel hydrogels of chitosan and poly(vinyl alcohol)-g-glycolic acid copolymer with enhanced rheological properties.壳聚糖和聚（乙烯醇）-g-聚（乙醇酸）共聚物的新型水凝胶，具有增强的流变性能。
Carbohydr Polym. 2014 Mar 15;103:267-73. doi: 10.1016/j.carbpol.2013.12.040. Epub 2013 Dec 21.
9
Synthesis, characterization and applications of N-quaternized chitosan/poly(vinyl alcohol) hydrogels.N-季铵化壳聚糖/聚乙烯醇水凝胶的合成、表征及应用
Int J Biol Macromol. 2015 Sep;80:149-61. doi: 10.1016/j.ijbiomac.2015.06.041. Epub 2015 Jun 24.
10
Facile preparation and characterization of super tough chitosan/poly(vinyl alcohol) hydrogel with low temperature resistance and anti-swelling property.简便制备具有耐低温和抗溶胀性能的超韧壳聚糖/聚乙烯醇水凝胶及其性能表征。
Int J Biol Macromol. 2020 Jan 1;142:574-582. doi: 10.1016/j.ijbiomac.2019.09.132. Epub 2019 Nov 15.

引用本文的文献

1
Advances in Nanohybrid Hydrogels for Wound Healing: From Functional Mechanisms to Translational Prospects.用于伤口愈合的纳米杂化水凝胶的进展：从功能机制到转化前景
Gels. 2025 Jun 23;11(7):483. doi: 10.3390/gels11070483.
2
Antibacterial Crosslinker for Ternary PCL-Reinforced Hydrogels Based on Chitosan, Polyvinyl Alcohol, and Gelatin for Tissue Engineering.用于基于壳聚糖、聚乙烯醇和明胶的三元聚己内酯增强水凝胶的抗菌交联剂，用于组织工程
Polymers (Basel). 2025 May 29;17(11):1520. doi: 10.3390/polym17111520.
3
Preparation and Characterization of Poly(vinyl-alcohol)/Chitosan Polymer Blend Films Chemically Crosslinked with Glutaraldehyde: Mechanical and Thermal Investigations.
用戊二醛化学交联的聚乙烯醇/壳聚糖聚合物共混膜的制备与表征：力学和热学研究
Molecules. 2024 Dec 14;29(24):5914. doi: 10.3390/molecules29245914.
4
The application of hydrogels for enamel remineralization.水凝胶在牙釉质再矿化中的应用。
Heliyon. 2024 Jun 25;10(13):e33574. doi: 10.1016/j.heliyon.2024.e33574. eCollection 2024 Jul 15.
5
Switchable adhesive films of pullulan loaded with a deep eutectic solvent-curcumin formulation for the photodynamic treatment of drug-resistant skin infections.负载有低共熔溶剂-姜黄素制剂的普鲁兰多糖可切换粘附膜用于耐药性皮肤感染的光动力治疗。
Mater Today Bio. 2023 Jul 14;22:100733. doi: 10.1016/j.mtbio.2023.100733. eCollection 2023 Oct.
6
Composite Hydrogels Based on Cross-Linked Chitosan and Low Molecular Weight Hyaluronic Acid for Tissue Engineering.基于交联壳聚糖和低分子量透明质酸的复合水凝胶用于组织工程
Polymers (Basel). 2023 May 19;15(10):2371. doi: 10.3390/polym15102371.
7
Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury.水凝胶作为递送系统和支架在继发性脊髓损伤治疗中的研究进展
Front Bioeng Biotechnol. 2023 Jan 18;11:1111882. doi: 10.3389/fbioe.2023.1111882. eCollection 2023.
8
Hydrophobisation of Silica Nanoparticles Using Lauroyl Ethyl Arginate and Chitosan Mixtures to Induce the Foaming Process.使用月桂酰基乙基精氨酸酯和壳聚糖混合物对二氧化硅纳米颗粒进行疏水化处理以引发发泡过程。
Polymers (Basel). 2022 Sep 28;14(19):4076. doi: 10.3390/polym14194076.
9
Development of Polymeric-Based Formulation as Potential Smart Colonic Drug Delivery System.基于聚合物的制剂作为潜在的智能结肠给药系统的开发。
Polymers (Basel). 2022 Sep 5;14(17):3697. doi: 10.3390/polym14173697.
10
Physicochemical Properties and Antibacterial Activity of Gellan Gum Incorporating Zinc Oxide/Carbon Nanotubes Bionanocomposite Film for Wound Healing.用于伤口愈合的含氧化锌/碳纳米管生物纳米复合膜的结冷胶的物理化学性质及抗菌活性
Bioinorg Chem Appl. 2022 Aug 28;2022:3158404. doi: 10.1155/2022/3158404. eCollection 2022.