Shrestha Annie, Kishen Anil
Discipline of Endodontics, University of Toronto, Toronto, Ontario, Canada.
Discipline of Endodontics, University of Toronto, Toronto, Ontario, Canada.
J Endod. 2016 Oct;42(10):1417-26. doi: 10.1016/j.joen.2016.05.021. Epub 2016 Aug 9.
A major challenge in root canal treatment is the inability of the current cleaning and shaping procedures to eliminate bacterial biofilms surviving within the anatomic complexities and uninstrumented portions of the root canal system.
Nanoparticles with their enhanced and unique physicochemical properties, such as ultrasmall sizes, large surface area/mass ratio, and increased chemical reactivity, have led research toward new prospects of treating and preventing dental infections. This article presents a comprehensive review on the scientific knowledge that is available on the application of antibacterial nanoparticles in endodontics.
The application of nanoparticles in the form of solutions for irrigation, medication, and as an additive within sealers/restorative materials has been evaluated to primarily improve the antibiofilm efficacy in root canal and restorative treatments. In addition, antibiotic or photosensitizer functionalized nanoparticles have been proposed recently to provide more potent antibacterial efficacy.
The increasing interest in this field warrants sound research based on scientific and clinical collaborations to emphasize the near future potential of nanoparticles in clinical endodontics.
根管治疗中的一个主要挑战是，当前的清洁和塑形程序无法清除在根管系统的解剖复杂性区域和未预备部分中存活的细菌生物膜。
纳米颗粒具有增强的独特物理化学性质，如超小尺寸、大的表面积/质量比和增强的化学反应性，这为治疗和预防牙科感染带来了新的研究前景。本文全面综述了抗菌纳米颗粒在牙髓病学应用方面的现有科学知识。
已对纳米颗粒以溶液形式用于冲洗、给药以及作为封闭剂/修复材料中的添加剂的应用进行了评估，主要目的是提高根管和修复治疗中的抗生物膜效果。此外，最近有人提出使用抗生素或光敏剂功能化的纳米颗粒以提供更强的抗菌效果。
该领域日益增长的关注度促使基于科学与临床合作开展合理的研究，以突出纳米颗粒在临床牙髓病学中的近期潜力。
