Human Brain Research Center Kyoto University Graduate School of Medicine Kyoto Japan.
Institute of Economic Research Kyoto University Kyoto Japan.
Brain Behav. 2016 Jun 16;6(8):e00503. doi: 10.1002/brb3.503. eCollection 2016 Aug.
Thought suppression has spurred extensive research in clinical and preclinical fields, particularly with regard to the paradoxical aspects of this behavior. However, the involvement of the brain's inhibitory system in the dynamics underlying the continuous effort to suppress thoughts has yet to be clarified. This study aims to provide a unified perspective for the volitional suppression of internal events incorporating the current understanding of the brain's inhibitory system.
Twenty healthy volunteers underwent functional magnetic resonance imaging while they performed thought suppression blocks alternating with visual imagery blocks. The whole dataset was decomposed by group-independent component analysis into 30 components. After discarding noise components, the 20 valid components were subjected to further analysis of their temporal properties including task-relatedness and between-component residual correlation.
Combining a long task period and a data-driven approach, we observed a right-side-dominant, lateral frontoparietal network to be strongly suppression related. This network exhibited increased fluctuation during suppression, which is compatible with the well-known difficulty of suppression maintenance.
Between-network correlation provided further insight into the coordinated engagement of the executive control and dorsal attention networks, as well as the reciprocal activation of imagery-related components, thus revealing neural substrates associated with the rivalry between intrusive thoughts and the suppression process.
思维抑制在临床和临床前领域引发了广泛的研究，特别是关于这种行为的矛盾方面。然而，大脑抑制系统在抑制思维的持续努力中所起的作用仍有待阐明。本研究旨在为包含大脑抑制系统当前认识的内部事件的意志性抑制提供一个统一的视角。
20 名健康志愿者在执行思维抑制块和视觉意象块交替任务时接受功能磁共振成像。全数据集通过组独立成分分析分解为 30 个成分。在丢弃噪声成分后，对 20 个有效成分进行了进一步的时间特性分析，包括与任务相关的和成分之间的剩余相关性。
通过结合长任务期和数据驱动方法，我们观察到一个右侧优势、侧额顶叶网络与抑制密切相关。该网络在抑制期间表现出波动增加，这与众所周知的抑制维持困难一致。
网络间相关性进一步揭示了执行控制和背侧注意网络的协调参与，以及与意象相关成分的相互激活，从而揭示了与侵入性思维和抑制过程竞争相关的神经基质。
