Kang Chang-Ho, So Jae-Seong
Department of Biological Engineering, Inha University, Republic of Korea.
Department of Biological Engineering, Inha University, Republic of Korea.
Mar Pollut Bull. 2016 Nov 15;112(1-2):111-116. doi: 10.1016/j.marpolbul.2016.08.033. Epub 2016 Aug 20.
The aim of the present study was to determine the antibiotic resistance patterns and distribution of heavy-metal resistance in Shewanella putrefaciens strains isolated from shellfishes collected from West Sea; and to determine the relationship, if any, between antibiotic and heavy-metal resistance in these strains. Among the 15 strains isolated, two strains, SY1 and SY2, showed heavy-metal resistance in addition to high resistance to seven antibiotics: cephalothin, gentamicin, erythromycin, vancomycin, ampicillin, rifampicin, and streptomycin. We conclude that heavy-metal contamination imposes long-term, widespread, and recalcitrant selection pressure, which potentially contributes to the maintenance and spread of antibiotic resistance factors in bacteria. Moreover, this fact holds both environmental and clinical importance.
本研究的目的是确定从西海采集的贝类中分离出的腐败希瓦氏菌菌株的抗生素耐药模式和重金属耐药性分布；并确定这些菌株中抗生素耐药性与重金属耐药性之间是否存在关系。在分离出的15株菌株中，SY1和SY2这两株菌株除了对七种抗生素（头孢噻吩、庆大霉素、红霉素、万古霉素、氨苄青霉素、利福平、链霉素）具有高耐药性外，还表现出重金属耐药性。我们得出结论，重金属污染施加了长期、广泛且顽固的选择压力，这可能有助于细菌中抗生素耐药因子的维持和传播。此外，这一事实具有环境和临床双重重要性。
