Chang Jingling, Zhang Hua, Tan Zhongjian, Xiao Juan, Li Shuren, Gao Ying
Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyuncang, 100700, Beijing, Dongcheng District, China.
TCM EncePhaloPathy Treatment, Key Laboratory of Beijing University of Chinese Medicine, No. 5 Haiyuncang, 100700, Beijing, Dongcheng District, China.
Wien Klin Wochenschr. 2017 Feb;129(3-4):102-109. doi: 10.1007/s00508-016-1070-1. Epub 2016 Sep 2.
In this study we investigated the neurolinguistic and neuroimaging characteristics of post-stroke motor aphasia patients. The effects of acupuncture on cortex activation by using magnetic resonance imaging (MRI) in patients with motor aphasia were also studied.
In this study 43 patients with motor aphasia after stroke were assessed according to Clinical Rehabilitation Research Center aphasia examination (CRRCAE) for linguistic evaluation and MRI and computed tomography (CT) were used for the analyses of brain lesions. The MRI imaging data were also examined using statistical parametric mapping (SPM8) software. Cortex activation images during acupuncture were analyzed using generalized linear model analysis.
The results of MRI and CT showed diverse brain lesion regions of post-stroke motor aphasia including the cortex, subcortex and cortex together with the subcortex. The language-related brain areas are activated by acupuncture including frontal, temporal, parietal and occipital lobes as well as insula, precuneus and other wide range of brain function areas as shown by MRI.
Our study showed that the brain lesion regions in post-stroke motor aphasia were not completely consistent with the classical motor speech center. By using MRI our study results suggest that the formation of cognitive language may be involved with the cortical-subcortical functional networks. Acupuncture may be useful for treatment of motor aphasia after stroke.
在本研究中，我们调查了中风后运动性失语患者的神经语言学和神经影像学特征。还研究了针刺对运动性失语患者皮质激活的磁共振成像（MRI）影响。
本研究中，43例中风后运动性失语患者根据临床康复研究中心失语症检查（CRRCAE）进行语言评估，并使用MRI和计算机断层扫描（CT）分析脑损伤。MRI成像数据也使用统计参数映射（SPM8）软件进行检查。针刺期间的皮质激活图像使用广义线性模型分析。
MRI和CT结果显示中风后运动性失语的脑损伤区域多样，包括皮质、皮质下以及皮质与皮质下联合区域。MRI显示针刺可激活与语言相关的脑区，包括额叶、颞叶、顶叶和枕叶以及脑岛、楔前叶和其他广泛的脑功能区。
我们的研究表明，中风后运动性失语的脑损伤区域与经典运动言语中枢并不完全一致。通过MRI研究结果表明，认知语言的形成可能与皮质-皮质下功能网络有关。针刺可能对中风后运动性失语的治疗有用。
