Huang Shishu, Liang Nuanyi, Hu Yang, Zhou Xin, Abidi Noureddine
Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Centre for Human Tissues and Organs Degeneration and Shenzhen Key Laboratory of Marine Biomedical Materials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.
Biomed Res Int. 2016;2016:2389895. doi: 10.1155/2016/2389895. Epub 2016 Aug 9.
Polydopamine (PDA) prepared in the form of a layer of polymerized dopamine (DA) in a weak alkaline solution has been used as a versatile biomimetic surface modifier as well as a broadly used immobilizing macromolecule. This review mainly discusses the progress of biomaterial surface modification inspired by the participation of PDA in bone tissue engineering. A comparison between PDA-assisted coating techniques and traditional surface modification applied to bone tissue engineering is first presented. Secondly, the chemical composition and the underlying formation mechanism of PDA coating layer as a unique surface modifier are interpreted and discussed. Furthermore, several typical examples are provided to evidence the importance of PDA-assisted coating techniques in the construction of bone biosubstitutes and the improvement of material biocompatibility. Nowadays, the application of PDA as a superior surface modifier in multifunctional biomaterials is drawing tremendous interests in bone tissue scaffolds to promote the osteointegration for bone regeneration.
在弱碱性溶液中以聚合多巴胺（DA）层形式制备的聚多巴胺（PDA），已被用作一种通用的仿生表面改性剂以及广泛使用的固定化大分子。本综述主要讨论了受PDA参与骨组织工程启发的生物材料表面改性进展。首先介绍了PDA辅助涂层技术与应用于骨组织工程的传统表面改性之间的比较。其次，对作为独特表面改性剂的PDA涂层的化学成分及其潜在形成机制进行了解释和讨论。此外，还提供了几个典型例子，以证明PDA辅助涂层技术在构建骨生物替代物和改善材料生物相容性方面的重要性。如今，PDA作为一种优异的表面改性剂在多功能生物材料中的应用，正引起骨组织支架领域的极大兴趣，以促进骨再生的骨整合。
