Mao Li, Li Wenliang, Yang Leilei, Wang Jianhui, Cheng Suping, Wei Yong, Wang Qiusheng, Zhang Wenwen, Hao Fei, Ding Yonglong, Sun Yinhua, Jiang Jieyuan
Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences; Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, National Center for Engineering Research of Veterinary Bio-products, Nanjing, 210014, China.
Suining Animal Husbandry and Veterinary station, Suining, 221200, China.
BMC Vet Res. 2016 Sep 5;12(1):181. doi: 10.1186/s12917-016-0820-7.
Bovine viral diarrhea virus (BVDV) is a pathogen of domestic and wildlife animals worldwide and is associated with several diseases. In China, there are many reports about genotyping of BVDV strains originated from cattle and pigs, and some of them focused on the geographical distributions of BVDV. Currently, the goat industry in Jiangsu province of China is under going a rapid expansion. Most of these goat farms are backyard enterprises and in close proximity to pig and cattle farms. However, there was very limited information about BVDV infections in goats. The objective of this study was to assess the frequency of BVDV infections of goats, the relationship of these infections to clinical signs and determine what BVDV genotypes are circulating in Jiangsu province.
From 236 goat sera collected from six regions in Jiangsu province between 2011 and 2013, BVDV-1 was identified in 29 samples from the five regions by RT-PCR. The BVDV-1 infections occurred with/without clinical signs. Eight different BVDV-1 strains were identified from these positive samples based on the 5'-untranslated region (5'-UTR) sequences, and further clustered into four BVDV-1 subtypes on the phylogenetic analysis. Three were BVDV-1b, two BVDV-1m, two BVDV-1o, and one BVDV-1p, respectively.
To our knowledge, this is the first report to investigate the occurrence of BVDV and the genotypes of BVDV infecting goats in China. The results indicated that BVDV-1 infections were indeed present and the viruses were with genetic variations in Chinese goat herds. The information would be very useful for prevention and control of BVDV-1 infections in China.
牛病毒性腹泻病毒（BVDV）是一种在全球家养动物和野生动物中传播的病原体，与多种疾病相关。在中国，有许多关于源自牛和猪的BVDV毒株基因分型的报道，其中一些关注了BVDV的地理分布。目前，中国江苏省的山羊产业正在迅速扩张。这些山羊养殖场大多是家庭式企业，且与猪场和牛场相邻。然而，关于山羊感染BVDV的信息非常有限。本研究的目的是评估山羊BVDV感染的频率、这些感染与临床症状的关系，并确定江苏省流行的BVDV基因型。
在2011年至2013年期间从江苏省六个地区采集的236份山羊血清中，通过RT-PCR在五个地区的29份样本中鉴定出了BVDV-1。BVDV-1感染出现时有/无临床症状。根据5'-非翻译区（5'-UTR）序列，从这些阳性样本中鉴定出8种不同的BVDV-1毒株，并在系统发育分析中进一步聚类为4种BVDV-1亚型。分别有3株BVDV-1b、2株BVDV-1m、2株BVDV-1o和1株BVDV-1p。
据我们所知，这是中国首次调查山羊中BVDV的发生情况以及感染山羊的BVDV基因型的报告。结果表明，中国山羊群中确实存在BVDV-1感染，且病毒存在基因变异。这些信息对于中国预防和控制BVDV-1感染非常有用。
