Kang Heerim, Lee Chang Hyung, Kim Jong Rhan, Kwon Jung Yeon, Son Myoung-Jin, Kim Jong-Eun, Lee Ki Won
Major in Biomodulation, Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-742, Republic of Korea; Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.
Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Food Chem. 2017 Feb 1;216:19-26. doi: 10.1016/j.foodchem.2016.07.141. Epub 2016 Jul 27.
Cacao beans from Theobroma cacao are an abundant source of polyphenols, particularly flavonoids. Previous studies demonstrated that cacao flavanols decrease pro-inflammatory cytokines resulting in the alleviation of allergic symptoms. We sought to investigate the effects of cacao extract (CE) on Dermatophagoides farinae extract (DFE)-induced atopic dermatitis (AD)-like symptoms. CE attenuated DFE-induced AD-like symptoms as assessed by skin lesion analyses, dermatitis score, and skin thickness. Histopathological analysis revealed that CE suppressed DFE-induced immune cell infiltration into the skin. These observations occurred concomitantly with the downregulation of inflammatory markers including serum immunoglobulin (Ig) E, chemokine; thymus and activation-regulated chemokine and macrophage-derived chemokine as well as the skin-derived cytokines interleukin (IL)-4, IL-5, and interferon-γ. CE also significantly alleviated transepidermal water loss and increased skin hydration. These results suggest that CE, a natural phytochemical-rich food, has potential therapeutic efficacy for the treatment of AD.
来自可可树的可可豆是多酚类物质的丰富来源，尤其是黄酮类化合物。先前的研究表明，可可黄烷醇可降低促炎细胞因子，从而减轻过敏症状。我们试图研究可可提取物（CE）对粉尘螨提取物（DFE）诱发的类特应性皮炎（AD）症状的影响。通过皮肤损伤分析、皮炎评分和皮肤厚度评估发现，CE减轻了DFE诱发的类AD症状。组织病理学分析显示，CE抑制了DFE诱导的免疫细胞浸润到皮肤中。这些观察结果同时伴随着炎症标志物的下调，包括血清免疫球蛋白（Ig）E、趋化因子；胸腺和活化调节趋化因子以及巨噬细胞衍生趋化因子，以及皮肤衍生细胞因子白细胞介素（IL）-4、IL-5和干扰素-γ。CE还显著减轻了经表皮水分流失并增加了皮肤水合作用。这些结果表明，CE作为一种富含天然植物化学物质的食物，对AD的治疗具有潜在的治疗效果。
