Dai Lianpan, Wang Qihui, Qi Jianxun, Shi Yi, Yan Jinghua, Gao George F
Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.
CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
IUBMB Life. 2016 Oct;68(10):783-91. doi: 10.1002/iub.1556. Epub 2016 Sep 7.
Antibody-mediated humoral immunity plays a pivotal role in flavivirus control. Neutralizing antibodies targeting viral envelope (E) protein, provide protection against flaviviruses in vivo but can also promote virus infection by antibody-dependent enhancement when antibodies are weakly neutralizing or in subneutralizing concentrations. The molecular basis for antibody-mediated virus neutralization can be revealed by structural studies of monoclonal antibodies complexed with the E protein or virion. In addition, the flavivirus non-structural protein NS1 can also induce host antibody production, and some of these antibodies can provide protection against virus challenge. In this review, we summarize the known structures of flavivirus neutralizing or protective antibodies bound to their epitopes and describe the underlying molecular mechanisms. © 2016 IUBMB Life, 68(10):783-791, 2016.
抗体介导的体液免疫在黄病毒控制中起关键作用。靶向病毒包膜（E）蛋白的中和抗体在体内提供针对黄病毒的保护，但当抗体为弱中和性或处于亚中和浓度时，也可通过抗体依赖增强作用促进病毒感染。与E蛋白或病毒粒子复合的单克隆抗体的结构研究可以揭示抗体介导的病毒中和的分子基础。此外，黄病毒非结构蛋白NS1也可诱导宿主抗体产生，其中一些抗体可提供针对病毒攻击的保护。在本综述中，我们总结了与表位结合的黄病毒中和或保护性抗体的已知结构，并描述了潜在的分子机制。©2016国际生物化学与分子生物学联盟生命科学部，68(10):783 - 791, 2016。
