Owens Robert L, Gold Kathryn A, Gozal David, Peppard Paul E, Jun Jonathan C, Dannenberg Andrew J, Lippman Scott M, Malhotra Atul
Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California.
Moores Cancer Center, University of California San Diego, La Jolla, California.
Cancer Prev Res (Phila). 2016 Nov;9(11):821-827. doi: 10.1158/1940-6207.CAPR-16-0092. Epub 2016 Sep 7.
Sleep, like eating and breathing, is an essential part of the daily life cycle. Although the science is still emerging, sleep plays an important role in immune, cardiovascular, and neurocognitive function. Despite its great importance, nearly 40% of U.S. adults experience problems with sleep ranging from insufficient total sleep time, trouble initiating or maintaining sleep (Insomnia), circadian rhythm disorders, sleep-related movement disorders, and sleep-related breathing disorders such as obstructive sleep apnea (OSA). Herein, we discuss new evidence that suggests that sleep may also affect carcinogenesis. Specifically, we review recent epidemiologic data suggesting links between cancer and OSA. As OSA is a common, underdiagnosed, and undertreated condition, this has public health implications. Intriguing animal model data support a link between cancer and sleep/OSA, although mechanisms are not yet clear. Leaders in the fields of sleep medicine, pulmonology, and oncology recently met to review and discuss these data, as well as to outline future directions of study. We propose a multidisciplinary, three-pronged approach to studying the associations between cancer and sleep, utilizing mutually interactive epidemiologic studies, preclinical models, and early-phase clinical trials. Cancer Prev Res; 9(11); 821-7. ©2016 AACR.
睡眠，如同饮食和呼吸一样，是日常生活周期的重要组成部分。尽管相关科学仍在不断发展，但睡眠在免疫、心血管和神经认知功能方面发挥着重要作用。尽管其至关重要，但近40%的美国成年人存在睡眠问题，包括总睡眠时间不足、入睡或维持睡眠困难（失眠）、昼夜节律紊乱、与睡眠相关的运动障碍以及与睡眠相关的呼吸障碍，如阻塞性睡眠呼吸暂停（OSA）。在此，我们讨论新的证据，这些证据表明睡眠可能也会影响癌症发生。具体而言，我们回顾近期的流行病学数据，这些数据提示癌症与OSA之间存在联系。由于OSA是一种常见、诊断不足且治疗不足的病症，这具有公共卫生意义。有趣的动物模型数据支持癌症与睡眠/OSA之间存在联系，尽管其机制尚不清楚。睡眠医学、肺病学和肿瘤学领域的领军人物最近会面，对这些数据进行了回顾和讨论，并概述了未来的研究方向。我们提出一种多学科、三管齐下的方法来研究癌症与睡眠之间的关联，利用相互作用的流行病学研究、临床前模型和早期临床试验。《癌症预防研究》；9(11)；821 - 827。©2016美国癌症研究协会。
