Jacob Louis, Keil Thomas, Kostev Karel
Department of Biology, École Normale Supérieure de Lyon, Lyon, France.
Institute for Social Medicine, Epidemiology and Health Economics, Charité - University Clinic Berlin, Berlin, Germany.
Pediatr Allergy Immunol. 2016 Dec;27(8):861-866. doi: 10.1111/pai.12656. Epub 2016 Oct 5.
Using routine healthcare data, the goal of this study was to examine the association between asthma and comorbid disorders in children in Germany.
Patients with a diagnosis of asthma documented by a German pediatrician in 2015 were identified. Demographic data included age and gender. Patients younger than 6 and older than 17 and individuals followed for less than a year before index date were excluded. Each patient was matched for age, sex, and physician with an asthma-free control. A total of 34,305 cases and 34,305 controls were available for analysis. There were three different age groups: 6-9 years, 10-13 years, and 14-17 years. Several disorders known to be associated with asthma or found in more than 1% of children and adolescents were also determined on the basis of primary care diagnoses. A multivariate logistic regression model was used to estimate the association between asthma and comorbid disorders.
The mean age was 10.9 years, and 61.6% of the subjects were boys. The most common diseases found in the three age groups were vasomotor and allergic rhinitis, chronic bronchitis, chronic rhinitis, pneumonia, and atopic dermatitis. These five comorbid disorders were associated with asthma to a significant extent.
Overall, this study, based on primary healthcare data, found a considerably high prevalence of several comorbid diseases in German children with asthma.
本研究旨在利用常规医疗数据，调查德国儿童哮喘与共病之间的关联。
确定2015年由德国儿科医生诊断为哮喘的患者。人口统计学数据包括年龄和性别。排除6岁以下、17岁以上以及在索引日期前随访不到一年的个体。为每位患者匹配年龄、性别和医生均相同的无哮喘对照。共有34305例病例和34305例对照可供分析。分为三个不同年龄组：6 - 9岁、10 - 13岁和14 - 17岁。还根据初级保健诊断确定了几种已知与哮喘相关或在超过1%的儿童和青少年中发现的疾病。采用多因素逻辑回归模型来估计哮喘与共病之间的关联。
平均年龄为10.9岁，61.6%的受试者为男性。在三个年龄组中发现的最常见疾病是血管运动性鼻炎和过敏性鼻炎、慢性支气管炎、慢性鼻炎、肺炎和特应性皮炎。这五种共病与哮喘有显著关联。
总体而言，这项基于初级医疗数据的研究发现，德国哮喘儿童中几种共病的患病率相当高。
