Sanz Anquela J M, Muñoz González M L, Ruiz Liso J M, Rodríguez Manzanilla L, Alfaro Torres J
Rev Esp Enferm Apar Dig. 1989 Jun;75(6 Pt 1):561-5.
Diverse previous epidemiological studies have associated the risk of gastric cancer (CG) with the nitrate content of drinking water in certain high risk areas in Columbia and Denmark, but in other countries no relation has been found and the topic is still controversial. In the present study and analysis is made of the differential risk of gastric cancer in the province of Soria (Spain) in terms of mortality and incidence in each of the natural regions of this province, investigating an eventual correlation with the nitrate content of the drinking water. Although the maximum nitrate content found barely exceeded the maximum limits suggested by the WHO, these values have a statistically significant positive linear correlation with the adjusted mortality (p less than 0.01) and incidence rates of gastric cancer in men (p less than 0.05). The authors discuss the need for further investigation of the topic in Spain since the nitrate values encountered might not reflect the true magnitude of environmental nitrate exposure, or there could be other factors related to agricultural work in the grain-producing regions where the maximum rates of gastric cancer in men are recorded.
以往多项流行病学研究已将哥伦比亚和丹麦某些高危地区的胃癌风险与饮用水中的硝酸盐含量联系起来,但在其他国家尚未发现这种关联,该话题仍存在争议。在本研究中,对西班牙索里亚省胃癌的不同风险进行了分析,依据该省各自然区域的死亡率和发病率展开调查,探究其与饮用水中硝酸盐含量之间的潜在关联。尽管所发现的硝酸盐最大含量仅略高于世界卫生组织建议的上限,但这些数值与男性胃癌的调整死亡率(p小于0.01)和发病率(p小于0.05)存在统计学上显著的正线性相关。作者讨论了在西班牙对该话题进行进一步调查的必要性,因为所遇到的硝酸盐值可能无法反映环境硝酸盐暴露的真实程度,或者在记录男性胃癌发病率最高的谷物产区,可能存在与农业工作相关的其他因素。