Ayyad Seif-Eldin N, Alarif Walied M, Al-Footy Khalid O, Selim Elham A, Ghandourah Mohamed A, Aly Magda M, Alorfi Hajer S
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
Department of Chemistry, Faculty of Science, Damietta University, Damietta, Egypt.
Z Naturforsch C J Biosci. 2017 Jan 1;72(1-2):27-34. doi: 10.1515/znc-2015-0228.
A new C-30 steroid, 3β-,5α-,6β-,11α-,20β-pentahydroxygorgosterol (1), and a new diterpenoid, xeniumbellal (2), along with three known aromadendrane-type sesquiterpenes, aromadendrene (3), palustrol (4) and viridiflorol (5), were isolated from the soft coral Xenia umbellata. Chemical structures were determined by analyzing their NMR and MS data. The antimicrobial and antitumor activities of the isolated compounds were examined. Both 1 and 2 showed moderate antibacterial activities, especially against the multidrug-resistant Acinetobacter baumannii (MIC 0.22 and 0.28 mM, respectively); while 2 showed antitumor activity against a lymphoma cell line with LD50 0.57 mM and was nontoxic to Artemia salina at all tested concentrations up to about 4 mM.
从软珊瑚伞花异柳珊瑚（Xenia umbellata）中分离出一种新的C-30甾体化合物3β,5α,6β,11α,20β-五羟基戈尔戈甾醇（1）和一种新的二萜类化合物伞花异柳萜（2），以及三种已知的芳樟烷型倍半萜类化合物，即芳樟烯（3）、沼生红没药醇（4）和绿花白千层醇（5）。通过分析它们的核磁共振（NMR）和质谱（MS）数据确定了化学结构。对分离出的化合物的抗菌和抗肿瘤活性进行了检测。化合物1和2均表现出中等抗菌活性，尤其对多重耐药鲍曼不动杆菌（MIC分别为0.22和0.28 mM）；而化合物2对一种淋巴瘤细胞系具有抗肿瘤活性，LD50为0.57 mM，在高达约4 mM的所有测试浓度下对卤虫均无毒。
