Oliver Jonathan M, Stoner Lee, Rowlands David S, Caldwell Aaron R, Sanders Elizabeth, Kreutzer Andreas, Mitchell Joel B, Purpura Martin, Jäger Ralf
Department of Kinesiology, Texas Christian University, TCU Box 297730, Fort Worth, TX 76129, USA.
School of Sport and Exercise, Massey University, 63 Wallace Street, Wellington 6021, New Zealand.
J Nutr Metab. 2016;2016:1089653. doi: 10.1155/2016/1089653. Epub 2016 Aug 17.
Curcumin, a turmeric extract, may protect against cardiovascular diseases by enhancing endothelial function. In this randomized controlled double-blind parallel prospective study, fifty-nine healthy adults were assigned to placebo, 50 mg (50 mg), or 200 mg (200 mg) curcumin, for 8 weeks. The higher curcumin (200 mg) supplementation produced a dose-mediated improvement in endothelial function measured by flow-mediated dilation (FMD). The outcome was a clinically substantial 3.0% increase (90% CI 0.7 to 5.3%, p = 0.032; benefit : harm odds ratio 546 : 1) with the 200 mg dose, relative to placebo. The 50 mg dose also increased FMD relative to placebo by 1.7% (-0.6 to 4.0%, p = 0.23; 25 : 1), but the outcome was not clinically decisive. In apparently healthy adults, 8 weeks of 200 mg oral curcumin supplementation resulted in a clinically meaningful improvement in endothelial function as measured by FMD. Oral curcumin supplementation may present a simple lifestyle strategy for decreasing the risk of cardiovascular diseases. This trial was registered at ISRCTN registry (ISRCTN90184217).
姜黄素是一种姜黄提取物，可能通过增强内皮功能来预防心血管疾病。在这项随机对照双盲平行前瞻性研究中，59名健康成年人被分配到安慰剂组、50毫克（50mg）姜黄素组或200毫克（200mg）姜黄素组，为期8周。较高剂量的姜黄素（200mg）补充剂通过血流介导的血管舒张（FMD）测量，在内皮功能方面产生了剂量介导的改善。相对于安慰剂，200mg剂量的结果在临床上有显著的3.0%的增加（90%CI 0.7至5.3%，p = 0.032；获益：伤害比值比546：1）。50mg剂量相对于安慰剂也使FMD增加了1.7%（-0.6至4.
