Deepagan V G, You Dong Gil, Um Wooram, Ko Hyewon, Kwon Seunglee, Choi Ki Young, Yi Gi-Ra, Lee Jun Young, Lee Doo Sung, Kim Kwangmeyung, Kwon Ick Chan, Park Jae Hyung
School of Chemical Engineering, College of Engineering, Sungkyunkwan University , Suwon 16419, Republic of Korea.
Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology , Seoul 02792, Republic of Korea.
Nano Lett. 2016 Oct 12;16(10):6257-6264. doi: 10.1021/acs.nanolett.6b02547. Epub 2016 Oct 3.
Although sonodynamic therapy (SDT) has emerged as a potential alternative to conventional photodynamic therapy, the low quantum yield of the sonosensitizer such as TiO nanoparticles (NPs) is still a major concern. Here, we have developed hydrophilized Au-TiO nanocomposites (HAu-TiO NCs) as sonosensitizers for improved SDT. The physicochemical properties of HAu-TiO NCs were thoroughly studied and compared with their counterparts without gold deposition. Upon exposure of HAu-TiO NCs to ultrasound, a large quantity of reactive oxygen species (ROS) were generated, leading to complete suppression of tumor growth after their systemic administration in vivo. Overall, it was evident that the composites of gold with TiO NPs significantly augmented the levels of ROS generation, implying their potential as SDT agents for cancer therapy.
尽管声动力疗法（SDT）已成为传统光动力疗法的一种潜在替代方法，但诸如TiO纳米颗粒（NPs）等声敏剂的低量子产率仍是一个主要问题。在此，我们开发了亲水化的Au-TiO纳米复合材料（HAu-TiO NCs）作为声敏剂以改善声动力疗法。对HAu-TiO NCs的物理化学性质进行了深入研究，并与未沉积金的对应物进行了比较。当HAu-TiO NCs暴露于超声时，会产生大量活性氧（ROS），在其体内全身给药后导致肿瘤生长完全受到抑制。总体而言，很明显金与TiO NPs的复合材料显著提高了ROS的产生水平，这意味着它们作为癌症治疗声动力疗法药物的潜力。
