Karim Nurul Ashikin Abd, Ibrahim Muhammad Din, Kntayya Saie Brindha, Rukayadi Yaya, Hamid Hazrulizawati Abd, Razis Ahmad Faizal Abdull
Laboratory of UPM-MAKNA Cancer Research, Institute of Bioscience, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia E-mail :
Asian Pac J Cancer Prev. 2016;17(8):3675-86.
Moringa oleifera Lam, family Moringaceae, is a perennial plant which is called various names, but is locally known in Malaysia as "murungai" or "kelor". Glucomoringin, a glucosinolate with from M. oleifera is a major secondary metabolite compound. The seeds and leaves of the plant are reported to have the highest amount of glucosinolates. M. oleifera is well known for its many uses health and benefits. It is claimed to have nutritional, medicinal and chemopreventive potentials. Chemopreventive effects of M. oleifera are expected due to the existence of glucosinolate which it is reported to have the ability to induce apoptosis in anticancer studies. Furthermore, chemopreventive value of M. oleifera has been demonstrated in studies utilizing its leaf extract to inhibit the growth of human cancer cell lines. This review highlights the advantages of M. oleifera targeting chemoprevention where glucosinolates could help to slow the process of carcinogenesis through several molecular targets. It is also includes inhibition of carcinogen activation and induction of carcinogen detoxification, anti-inflammatory, anti-tumor cell proliferation, induction of apoptosis and inhibition of tumor angiogenesis. Finally, for synergistic effects of M. oleifera with other drugs and safety, essential for chemoprevention, it is important that it safe to be consumed by human body and works well. Although there is promising evidence about M. oleifera in chemoprevention, extensive research needs to be done due to the expected rise of cancer in coming years and to gain more information about the mechanisms involved in M. oleifera influence, which could be a good source to inhibit several major mechanisms involved in cancer development.
辣木，辣木科，是一种多年生植物，有多种名称，但在马来西亚当地被称为“murungai”或“kelor”。辣木中的一种硫代葡萄糖苷——葡萄糖辣木素是主要的次生代谢产物化合物。据报道，该植物的种子和叶子中硫代葡萄糖苷含量最高。辣木因其诸多健康益处而闻名。据称它具有营养、药用和化学预防潜力。由于存在硫代葡萄糖苷，据报道其在抗癌研究中具有诱导细胞凋亡的能力，因此预计辣木有化学预防作用。此外，在利用其叶提取物抑制人类癌细胞系生长的研究中，已证明辣木具有化学预防价值。本综述强调了辣木在化学预防方面的优势，其中硫代葡萄糖苷可通过几个分子靶点帮助减缓致癌过程。它还包括抑制致癌物激活和诱导致癌物解毒、抗炎、抗肿瘤细胞增殖、诱导细胞凋亡以及抑制肿瘤血管生成。最后，为了辣木与其他药物的协同作用以及化学预防所必需的安全性，其对人体安全且效果良好很重要。尽管有关于辣木在化学预防方面的有前景的证据，但由于未来几年癌症预计会增加，且为了获取更多关于辣木影响所涉及机制的信息，仍需要进行广泛研究，辣木可能是抑制癌症发展所涉及的几种主要机制中的一个良好来源。
