Razzaque Mohammed S
Department of Applied Oral Sciences, Forsyth Institute, Cambridge, MA, USA; Department of Pathology, Saba University School of Medicine, Saba, Dutch Caribbean, Netherlands; Department of Oral Health Policy & Epidemiology, Harvard School of Dental Medicine, Boston, MA, USA; Department of Preventive & Community Dentistry, Rwanda University School of Dentistry, Kigali, Rwanda.
J Steroid Biochem Mol Biol. 2018 Jan;175:44-48. doi: 10.1016/j.jsbmb.2016.09.004. Epub 2016 Sep 16.
Vitamin D is a fat-soluble vitamin whose levels within the body are elevated following sunlight exposure. Numerous studies have shown that sunlight exposure can provide protection to a wide variety of diseases, ranging from different types of tumors to hypertension to type 1 diabetes to multiple sclerosis. Moreover, studies have shown that avoiding sunlight may influence the initiation and progression of some of these diseases. Avoidance of sunlight, coupled with the inclination towards consuming supplements, is becoming the primary choice to obtain vitamin D. The purpose of this article is to present evidences from published literature, to show that the expected benefits of vitamin D supplements are minimized by the potential risk of cardiovascular events and beyond. Since hypovitaminosis D status usually reflects reduced sunlight exposure, the obvious primary replacement should be safe sunlight exposure, and not exogenous supplements.
维生素D是一种脂溶性维生素，人体经阳光照射后其体内水平会升高。大量研究表明，阳光照射可预防多种疾病，从不同类型的肿瘤到高血压、1型糖尿病再到多发性硬化症。此外，研究还表明，避免阳光照射可能会影响其中一些疾病的发生和发展。避免阳光照射，再加上倾向于服用补充剂，正成为获取维生素D的主要选择。本文旨在展示已发表文献中的证据，表明维生素D补充剂的预期益处会因心血管事件及其他潜在风险而降至最低。由于维生素D缺乏状态通常反映阳光照射减少，明显的首要补充方式应是安全的阳光照射，而非外源性补充剂。
