生长速率在稳态和非稳态下控制mRNA周转。
Growth rate controls mRNA turnover in steady and non-steady states.
作者信息
García-Martínez José, Troulé Kevin, Chávez Sebastián, Pérez-Ortín José E
机构信息
a Departamento de Genética and E.R.I. Biotecmed , Universitat de València , Burjassot , Spain.
b Departamento de Bioquımica y Biologia Molecular and E.R.I. Biotecmed, Universitat de València , Burjassot , Spain.
出版信息
RNA Biol. 2016 Dec;13(12):1175-1181. doi: 10.1080/15476286.2016.1236171. Epub 2016 Sep 20.
Abstract
Gene expression has been investigated in relation with growth rate in the yeast Saccharomyces cerevisiae, following different experimental strategies. The expression of some specific gene functional categories increases or decreases with growth rate. Our recently published results have unveiled that these changes in mRNA concentration with growth depend on the relative alteration of mRNA synthesis and decay, and that, in addition to this gene-specific transcriptomic signature of growth, global mRNA turnover increases with growth rate. We discuss here these results in relation with other previous and concurrent publications, and we add new evidence which indicates that growth rate controls mRNA turnover even under non-steady-state conditions.
摘要
人们采用不同的实验策略，研究了酿酒酵母中基因表达与生长速率的关系。某些特定基因功能类别的表达会随着生长速率的增加或减少。我们最近发表的结果表明，mRNA浓度随生长的这些变化取决于mRNA合成和降解的相对变化，并且，除了这种生长的基因特异性转录组特征外，整体mRNA周转率也随生长速率增加。我们在此结合之前和同期的其他出版物讨论这些结果，并补充新的证据，表明即使在非稳态条件下，生长速率也能控制mRNA周转率。
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