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家猪中携带mecC的耐甲氧西林金黄色葡萄球菌报告。

Report of mecC-carrying MRSA in domestic swine.

作者信息

Angen Ø, Stegger M, Larsen J, Lilje B, Kaya H, Pedersen K S, Jakobsen A, Petersen A, Larsen A R

机构信息

Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark

Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark.

出版信息

J Antimicrob Chemother. 2017 Jan;72(1):60-63. doi: 10.1093/jac/dkw389. Epub 2016 Sep 20.

DOI:10.1093/jac/dkw389
PMID:27650187
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5161050/
Abstract

OBJECTIVES

We unexpectedly identified MRSA isolates carrying mecC (mecC-MRSA) from a Danish swine farm located in eastern Zealand. The objective of the present study was to investigate the origin of these isolates and their genetic relatedness to other mecC-MRSA isolates from Zealand.

METHODS

WGS was used to infer the phylogenetic relationship between 19 identified mecC-MRSA isolates from the swine farm and 34 additional epidemiologically unrelated human isolates from the same geographical region of Denmark. Variations in the accessory genome were investigated by bioinformatics tools, and antibiotic susceptibility profiles were assessed by MIC determination.

RESULTS

mecC-MRSA was isolated from a domestic swine farm, but not from cattle reared at the same farm. Phylogenetic analysis revealed that all mecC-MRSA isolates from both farm animals and workers formed a separate cluster, whereas human isolates from the same municipality belonged to a closely related cluster. Analysis of the accessory genome supported this relationship.

CONCLUSIONS

To the best of our knowledge, this is the first report of mecC-MRSA isolated from domestic swine. The investigation strongly indicates that transmission of mecC-MRSA has taken place on the swine farm between the farmers and swine. The close clustering of farm isolates and isolates from the same municipality suggests a local transmission of mecC-MRSA.

摘要

目的

我们意外地从西兰岛东部的一个丹麦养猪场中鉴定出携带mecC的耐甲氧西林金黄色葡萄球菌分离株（mecC-MRSA）。本研究的目的是调查这些分离株的来源以及它们与来自西兰岛的其他mecC-MRSA分离株的遗传相关性。

方法

采用全基因组测序（WGS）来推断养猪场中鉴定出的19株mecC-MRSA分离株与丹麦同一地理区域另外34株流行病学上无关的人类分离株之间的系统发育关系。通过生物信息学工具研究辅助基因组的变异情况，并通过最低抑菌浓度（MIC）测定评估抗生素敏感性谱。

结果

mecC-MRSA是从一个家养猪场分离得到的，但同一农场饲养的牛中未分离到。系统发育分析表明，来自农场动物和工人的所有mecC-MRSA分离株形成一个单独的聚类，而来自同一自治市的人类分离株属于一个密切相关的聚类。辅助基因组分析支持了这种关系。

结论

据我们所知，这是首次从家猪中分离出mecC-MRSA的报告。调查强烈表明，mecC-MRSA已在养猪场的农民和猪之间发生传播。农场分离株与来自同一自治市的分离株紧密聚类表明mecC-MRSA存在局部传播。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/5161050/bd20d7715512/dkw38901.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/5161050/bd20d7715512/dkw38901.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dac8/5161050/bd20d7715512/dkw38901.jpg

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