Solomon P R, Stowe G T, Pendlbeury W W
Department of Psychology, Williams College, Williamstown, Massachusetts 01267.
Behav Neurosci. 1989 Aug;103(4):898-902. doi: 10.1037//0735-7044.103.4.898.
A 54-year-old woman with damage to cerebellar circuitry resulting from a cerebrovascular accident underwent classical conditioning of the eye-blink response to a tone conditioned stimulus and an air-puff unconditioned stimulus. In contrast to 5 age-matched controls who readily acquired the conditioned response (CR), emitting a mean of 56.7 CRs over 70 trials, the patient emitted only 6 CRs in 100 trials and never emitted 2 consecutive CRs. There were no differences in spontaneous blink rate, sensitivity to the air puff, or sensitivity to the tone between the experimental subject and the control subjects. That conditioning of the eye-blink response is disrupted in a human with damage to cerebellar circuitry is consistent with an accumulating body of literature indicating that the cerebellum is the essential site of plasticity for classically conditioned somatic responses.
一名54岁女性因脑血管意外导致小脑神经回路受损，接受了对音调条件刺激和吹气非条件刺激的眨眼反应经典条件反射训练。与5名年龄匹配的对照者不同，这5名对照者很容易习得条件反应（CR），在70次试验中平均发出56.7次CR，而该患者在100次试验中仅发出6次CR，且从未连续发出2次CR。实验对象与对照对象在自发眨眼率、对吹气的敏感性或对音调的敏感性方面没有差异。小脑神经回路受损的人类中眨眼反应的条件反射受到破坏，这与越来越多的文献一致，这些文献表明小脑是经典条件反射性躯体反应可塑性的关键部位。
