Daum I, Schugens M M, Ackermann H, Lutzenberger W, Dichgans J, Birbaumer N
Department of Clinical and Physiological Psychology, University of Tübingen, Germany.
Behav Neurosci. 1993 Oct;107(5):748-56. doi: 10.1037//0735-7044.107.5.748.
We explored classical conditioning in human subjects who had lesions in their cerebellar circuitry. Seven patients with damage to cerebellar structures and matched control subjects underwent simple delay tone-airpuff conditioning. Eyelid conditioned response (CR) acquisition was severely disrupted in the patient group, whereas autonomic CRs and slow cortical potentials developing between conditioned stimulus (CS) and the unconditioned stimulus (UCS) were unaffected. Results are consistent with animal studies and earlier case reports indicating that intact cerebellar structures are necessary for the acquisition of classically conditioned motor responses.
我们对小脑神经回路受损的人类受试者进行了经典条件反射研究。七名小脑结构受损的患者和匹配的对照受试者接受了简单延迟音-吹气条件反射。患者组的眼睑条件反应（CR）习得严重受损，而自主CR以及在条件刺激（CS）和非条件刺激（UCS）之间产生的慢皮层电位未受影响。结果与动物研究和早期病例报告一致，表明完整的小脑结构对于经典条件反射性运动反应的习得是必要的。
