Xu Chao, Wei Qing-Kuan, Li Jin, Xiao Ting, Yin Kun, Zhao Chang-Lei, Wang Yong-Bin, Kong Xiang-Li, Zhao Gui-Hua, Sun Hui, Liu Xin, Huang Bing-Cheng
Shandong Academy of Medical Sciences, Shandong Institute of Parasitic Diseases, Shandong Provincial Reference Laboratory for Malaria Diagnosis, Jining, Shandong Province 272033, People's Republic of China.
Korean J Parasitol. 2016 Aug;54(4):407-14. doi: 10.3347/kjp.2016.54.4.407. Epub 2016 Aug 31.
Malaria remains a serious public health problem in Shandong Province, China; therefore, it is important to explore the characteristics of the current malaria prevalence situation in the province. In this study, data of malaria cases reported in Shandong during 2012-2014 were analyzed, and Plasmodium species were confirmed by smear microscopy and nested-PCR. A total of 374 malaria cases were reported, 80.8% of which were reported from 6 prefectures. Of all cases, P. falciparum was dominant (81.3%), followed by P. vivax (11.8%); P. ovale and P. malariae together accounted for 6.4% of cases. Notably, for the first time since 2012, no indigenous case had been reported in Shandong Province, a situation that continued through 2014. Total 95.2% of cases were imported from Africa. The ratio of male/female was 92.5:1, and 96.8% of cases occurred in people 20-54 years of age. Farmers or laborers represented 77.5% of cases. No significant trends of monthly pattern were found in the reported cases. All patients were in good condition after treatment, except for 3 who died. These results indicate that imported malaria has increased significantly since 2012 in Shandong Province, especially for P. falciparum, and there is an emergence of species diversity.
疟疾在中国山东省仍然是一个严重的公共卫生问题；因此，探索该省当前疟疾流行情况的特征很重要。在本研究中，分析了山东省2012 - 2014年报告的疟疾病例数据，并通过涂片显微镜检查和巢式PCR确认疟原虫种类。共报告了374例疟疾病例，其中80.8%来自6个地级市。在所有病例中，恶性疟原虫占主导地位（81.3%），其次是间日疟原虫（11.8%）；卵形疟原虫和三日疟原虫共占病例的6.4%。值得注意的是，自2012年以来山东省首次没有报告本土病例，这种情况一直持续到2014年。所有病例中有95.2%是从非洲输入的。男女比例为92.5:1，96.8%的病例发生在20 - 54岁的人群中。农民或劳动者占病例的77.5%。报告的病例中未发现明显的月度发病趋势。除3例死亡外，所有患者治疗后情况良好。这些结果表明，自2012年以来山东省输入性疟疾显著增加，尤其是恶性疟原虫，并且出现了种类多样性。
