López-Karpovitch X, Cardiel M, Cardenas R, Piedras J, Alarcón-Segovia D
Department of Hematology, Instituto Nacional de la Nutrición Salvador Zubirán, México.
Clin Exp Immunol. 1989 Jul;77(1):43-6.
In systemic lupus erythematosus (SLE) patients, in vitro bone marrow (BM) colony-forming units of granulocytes and monocytes/macrophages (CFU-GM) are decreased, suggesting that granulomonopoietic failure may play an important role in the mechanism of peripheral blood (PB) depletion of neutrophils and monocytes. No information concerning CFU-GM in PB of patients with SLE is available. The present study was undertaken in order to determine whether SLE itself and the inactive or active stage of disease would modify the number of GFU-GM in PB samples from 20 treatment-free SLE women, 12 inactive and eight active. CFU-GM growth was significantly decreased in both inactive (P = 0.018) and active (P = 0.008) SLE patients as compared with controls (n = 8). The difference in CFU-GM growth between SLE groups was not significant. These results indicate that the number of circulating CFU-GM is significantly reduced in patients with SLE regardless of disease activity or remission.
在系统性红斑狼疮（SLE）患者中，体外骨髓（BM）粒细胞和单核细胞/巨噬细胞集落形成单位（CFU-GM）减少，这表明粒单核细胞生成功能衰竭可能在中性粒细胞和单核细胞外周血（PB）减少的机制中起重要作用。目前尚无关于SLE患者PB中CFU-GM的信息。本研究旨在确定SLE本身以及疾病的非活动期或活动期是否会改变20名未经治疗的SLE女性（12名非活动期和8名活动期）PB样本中GFU-GM的数量。与对照组（n = 8）相比，非活动期（P = 0.018）和活动期（P = 0.008）SLE患者的CFU-GM生长均显著降低。SLE组之间CFU-GM生长的差异不显著。这些结果表明，无论疾病活动或缓解情况如何，SLE患者循环CFU-GM的数量均显著减少。
