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本文引用的文献

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Viremic control and viral coreceptor usage in two HIV-1-infected persons homozygous for CCR5 Δ32.两名CCR5 Δ32纯合的HIV-1感染者的病毒血症控制及病毒共受体使用情况
AIDS. 2015 May 15;29(8):867-76. doi: 10.1097/QAD.0000000000000629.
2
More on shift of HIV tropism in stem-cell transplantation with CCR5 delta32/delta32 mutation.更多关于CCR5 Δ32/Δ32突变的干细胞移植中HIV嗜性转变的研究。
N Engl J Med. 2014 Dec 18;371(25):2437-8. doi: 10.1056/NEJMc1412279.
3
HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.尽管接受了有效的抗逆转录病毒治疗,但CD4/CD8比率较低的HIV感染者表现出T细胞亚群改变、CD8+T细胞活化增强,以及非艾滋病相关发病和死亡风险增加。
PLoS Pathog. 2014 May 15;10(5):e1004078. doi: 10.1371/journal.ppat.1004078. eCollection 2014 May.
4
Soluble markers of inflammation and coagulation but not T-cell activation predict non-AIDS-defining morbid events during suppressive antiretroviral treatment.炎症和凝血的可溶性标志物而非T细胞活化可预测抗逆转录病毒抑制治疗期间的非艾滋病定义性病态事件。
J Infect Dis. 2014 Oct 15;210(8):1248-59. doi: 10.1093/infdis/jiu254. Epub 2014 May 1.
5
Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection.肠道上皮屏障功能障碍和先天免疫激活可预测接受治疗的HIV感染患者的死亡率。
J Infect Dis. 2014 Oct 15;210(8):1228-38. doi: 10.1093/infdis/jiu238. Epub 2014 Apr 21.
6
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.对感染 HIV 人群的自体 CD4 T 细胞中的 CCR5 进行基因编辑。
N Engl J Med. 2014 Mar 6;370(10):901-10. doi: 10.1056/NEJMoa1300662.
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Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease.炎症细胞因子驱动 CD4+T 细胞周期循环并损害对白细胞介素 7 的反应性:对 HIV 疾病免疫衰竭的影响。
J Infect Dis. 2014 Aug 15;210(4):619-29. doi: 10.1093/infdis/jiu125. Epub 2014 Feb 28.
8
Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy.抗逆转录病毒疗法对CD4 +细胞计数和病毒载量的反应对HIV-1阳性个体预期寿命的影响。
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9
Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues.持续性 HIV-1 复制与淋巴组织中抗逆转录病毒药物浓度降低有关。
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2307-12. doi: 10.1073/pnas.1318249111. Epub 2014 Jan 27.
10
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study.早期启动抗逆转录病毒治疗中断后实现长期病毒学缓解的治疗后HIV-1控制者:ANRS VISCONTI研究
PLoS Pathog. 2013 Mar;9(3):e1003211. doi: 10.1371/journal.ppat.1003211. Epub 2013 Mar 14.

治愈艾滋病毒感染:“我这辈子都等不到了”还是“近在咫尺”?

A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?

作者信息

Lederman Michael M, Cannon Paula M, Currier Judith S, June Carl H, Kiem Hans Peter, Kuritzkes Daniel R, Lewin Sharon R, Margolis David M, McCune Joseph M, Mellors John W, Schacker Timothy W, Sekaly Rafick P, Tebas Pablo, Walker Bruce D, Douek Daniel C

机构信息

Case Western Reserve University School of Medicine, Cleveland, OH.

University of Southern California, Los Angeles, CA.

出版信息

Pathog Immun. 2016 Spring;1(1):154-164. doi: 10.20411/pai.v1i1.133.

DOI:10.20411/pai.v1i1.133
PMID:27668293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5033048/
Abstract

With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding "a cure." The mere idea that cure of HIV might be possible has energized researchers and the community towards achieving this goal. Funding agencies, both governmental and private, have targeted HIV cure as a high priority; many in the field have responded to these initiatives and the cure research agenda is robust. In this "salon" two editors of , Michael Lederman and Daniel Douek ask whether curing HIV is a realistic, scalable objective. We start with an overview perspective and have asked a number of prominent HIV researchers to add to the discussion.

摘要

随着联合抗逆转录病毒疗法(ART)的出现并取得惊人成功,从而延长了HIV感染者的生命并提高了其生活质量,HIV研究有机会转向旨在寻找“治愈方法”的研究。仅仅是HIV有可能被治愈这一想法,就激励着研究人员和整个社会朝着实现这一目标努力。政府和私人的资助机构都将治愈HIV作为高度优先事项;该领域的许多人都对这些举措做出了回应,治愈研究议程进展顺利。在这个“沙龙”中,《》的两位编辑迈克尔·莱德曼(Michael Lederman)和丹尼尔·杜克(Daniel Douek)探讨了治愈HIV是否是一个现实且可扩展的目标。我们首先从一个概述的角度出发,并邀请了一些杰出的HIV研究人员参与讨论。