Sun Y, Fu D, Wang Y K, Liu M, Liu X D
Bratisl Lek Listy. 2016;117(9):521-524. doi: 10.4149/bll_2016_103.
To evaluate the prevalence of Helicobacter pylori (H. pylori, HP) infection in subjects receiving routine physical examination and its associations with age, sex, body mass index (BMI) and lipid profiles.
Clinical information of 22,103 individuals who took routine physical examinations, including that on age, gender, height, weight, triglyceride, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and data of HP infection were collected and analyzed.
H. pylori infection rate in 22,103 subjects taking routine physical examination was 44.5 %. More men tended to be infected with H. pylori than women (45.9 % vs 42.8 %; p < 0.01). The highest positive rate group was in the age group of 30-39 years (46.8 %) and the lowest rate was in the age group younger than 30 years (40.5 %). The obese had higher infection rate than the non-obese (p < 0.01). Mann-Whitney U test was used to explore the relationships between lipid profiles and H. pylori infection. There were significant associations among HDL, triglyceride and HP infection (p < 0.01). However, significant differences were not confirmed between cholesterol, LDL and H. pylori infection.
H. pylori infection was common among subjects receiving physical examination in Shanghai and it was most significantly associated with HDL and triglyceride, indicating that H. pylori might be a new cardiovascular risk factor (Tab. 3, Ref. 23).
评估接受常规体检人群中幽门螺杆菌（H. pylori，HP）感染的患病率及其与年龄、性别、体重指数（BMI）和血脂谱的关系。
收集并分析22103例接受常规体检者的临床信息，包括年龄、性别、身高、体重、甘油三酯、总胆固醇、高密度脂蛋白（HDL）胆固醇、低密度脂蛋白（LDL）胆固醇以及HP感染数据。
22103例接受常规体检者中HP感染率为44.5%。男性感染HP的倾向高于女性（45.9%对42.8%；p<0.01）。阳性率最高的组为30 - 39岁年龄组（46.8%），最低的为30岁以下年龄组（40.5%）。肥胖者感染率高于非肥胖者（p<0.01）。采用曼-惠特尼U检验探讨血脂谱与HP感染的关系。HDL、甘油三酯与HP感染之间存在显著关联（p<0.01）。然而，胆固醇、LDL与HP感染之间未证实有显著差异。
HP感染在上海接受体检的人群中很常见，且与HDL和甘油三酯关联最为显著，表明HP可能是一种新的心血管危险因素（表3，参考文献23）。
