Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Sapporo, Japan.
J Atheroscler Thromb. 2010 Oct 27;17(10):1041-8. doi: 10.5551/jat.5157. Epub 2010 Jul 2.
Helicobacter Pylori infection was associated with the risk of cardiovascular disease; however, the relation between Helicobacter Pylori infection and the lipid profile has not been fully established.
We measured anti-Helicobacter Pylori antibody concentration and lipid profiles in 6,289 Japanese subjects aged 21-64 years (5,077 male and 1,212 female).
The prevalence of Helicobacter Pylori-seropositive subjects was 46.8% and 39.6% in men and women, respectively. Adjusted mean values of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol in men were significantly higher and lower in Helicobacter Pylori-seropositive than-negative subjects, respectively, (LDL-cholesterol: 129.0±0.8 vs. 125.3±0.7 mg/dL, p< 0.001, HDL-cholesterol: 54.6±0.3 vs. 56.6±0.3 mg/dL, p< 0.01), whereas these associations were not significant in female subjects. Moreover, the odds ratio of Helicobacter Pylori infection for high LDL-cholesteremia and low HDL-cholesteremia in male subjects was 1.23 (95% CI (confidence interval): 1.08-1.40, p< 0.05) and 1.29 (95% CI: 1.03-1.59, p< 0.05), respectively. Female subjects did not have such associations.
The present study demonstrates that Helicobacter Pylori infection is significantly associated with high LDL-cholesteremia and low HDL-cholesteremia in Japanese male subjects.
幽门螺杆菌感染与心血管疾病风险相关；然而，幽门螺杆菌感染与血脂谱之间的关系尚未完全确定。
我们测量了 6289 名 21-64 岁的日本受试者的抗幽门螺杆菌抗体浓度和血脂谱，其中包括 5077 名男性和 1212 名女性。
幽门螺杆菌血清阳性受试者的患病率分别为男性 46.8%和女性 39.6%。男性幽门螺杆菌血清阳性组的低密度脂蛋白（LDL）胆固醇和高密度脂蛋白（HDL）胆固醇的调整平均值分别显著高于和低于血清阴性组（LDL-胆固醇：129.0±0.8 与 125.3±0.7 mg/dL，p<0.001，HDL-胆固醇：54.6±0.3 与 56.6±0.3 mg/dL，p<0.01），而在女性受试者中这些关联并不显著。此外，男性受试者中幽门螺杆菌感染与高 LDL 血症和低 HDL 血症的比值比分别为 1.23（95%可信区间（CI）：1.08-1.40，p<0.05）和 1.29（95%CI：1.03-1.59，p<0.05）。女性受试者没有这种关联。
本研究表明，幽门螺杆菌感染与日本男性受试者的高 LDL 血症和低 HDL 血症显著相关。
