Boctor F N, Charmy R A, Cooper E L
Specialty Laboratories, Inc., Santa Monica, CA 90404-3900.
Immunol Invest. 1989 Jul;18(6):775-84. doi: 10.3109/08820138909030598.
To test the hypothesis that there are circannual differences in mitotic activity in males and females, normal human peripheral blood lymphocytes were stimulated with suboptimal concentrations of Phytohemagglutinin (PHA), Concanavalin A (Con A) and Poke weed mitogen (PWM) over two summer/winter cycles. Lymphocyte responses for the entire population were significantly higher in the summer than in the winter. The same results were observed when responses were compared between a summer and a successive winter. However, when male and child-bearing age female responses were compared, females showed a higher significant difference for PHA and Con A between summer and winter, but not for PWM. These different responses due to season may reflect a relationship between the neuroendocrine and immune systems. At the cell level, these results suggest that an inherent difference exists between female and male lymphocytes and that these lymphocytes are sensitive to seasonal changes.
为了验证男性和女性有丝分裂活性存在周年差异这一假设，在两个夏/冬周期内，用次优浓度的植物血凝素（PHA）、刀豆蛋白A（Con A）和商陆有丝分裂原（PWM）刺激正常人类外周血淋巴细胞。整个人群的淋巴细胞反应在夏季显著高于冬季。当比较夏季和紧接着的冬季之间的反应时，观察到了相同的结果。然而，当比较男性和育龄女性的反应时，女性在夏季和冬季之间对PHA和Con A的差异更为显著，但对PWM则不然。这些因季节导致的不同反应可能反映了神经内分泌系统和免疫系统之间的关系。在细胞水平上，这些结果表明，女性和男性淋巴细胞之间存在内在差异，并且这些淋巴细胞对季节变化敏感。
