Gaffney G R, Kuperman S, Tsai L Y, Minchin S
J Am Acad Child Adolesc Psychiatry. 1989 Jul;28(4):534-7. doi: 10.1097/00004583-198907000-00011.
Researchers implicate central nervous system dysfunction in infantile autism, but postmortem examinations and in vivo brain imaging studies have produced conflicting results concerning the neuronal systems involved. Magnetic resonance imaging--a new modality of in vivo brain imaging--was used to investigate the cerebral and thalamic structure of 105 autistic patients. Compared with the control group, there was an overall difference in the forebrain morphology of the autistic subjects due to subtle but statistically significant differences in the anterior ventricular horns, lateral ventricles, and the right lenticular nucleus. These results, when considered with previous studies of cerebral structure, suggest that there are subtle alterations in the forebrain of autistic patients.
研究人员认为中枢神经系统功能障碍与婴儿自闭症有关，但尸检和活体脑成像研究在涉及的神经元系统方面得出了相互矛盾的结果。磁共振成像——一种活体脑成像的新方法——被用于研究105名自闭症患者的大脑和丘脑结构。与对照组相比，自闭症受试者的前脑形态存在总体差异，这是由于前脑室角、侧脑室和右侧豆状核存在细微但具有统计学意义的差异。这些结果与之前关于脑结构的研究结果相结合，表明自闭症患者的前脑存在细微改变。
