Ashburner J, Hutton C, Frackowiak R, Johnsrude I, Price C, Friston K
Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK.
Hum Brain Mapp. 1998;6(5-6):348-57. doi: 10.1002/(SICI)1097-0193(1998)6:5/6<348::AID-HBM4>3.0.CO;2-P.
The aim of this paper is to illustrate a method for identifying macroscopic anatomical differences among the brains of different populations of subjects. The method involves spatially normalizing the structural MR images of a number of subjects so that they all conform to the same stereotactic space. Multivariate statistics are then applied to the parameters describing the estimated nonlinear deformations that ensue. To illustrate the method, we compared the gross morphometry of male and female subjects. We also assessed brain asymmetry, the effect of handedness, and interactions among these effects.
本文的目的是阐述一种识别不同人群大脑之间宏观解剖学差异的方法。该方法包括对多名受试者的结构磁共振图像进行空间归一化，使其都符合相同的立体定向空间。然后将多元统计应用于描述随之产生的估计非线性变形的参数。为了说明该方法，我们比较了男性和女性受试者的总体形态测量。我们还评估了脑不对称性、利手的影响以及这些影响之间的相互作用。
