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德-克维恩甲状腺炎:手术经验回顾

de Quervain's thyroiditis: A review of experience with surgery.

作者信息

Ranganath Rohit, Shaha Manish A, Xu Bin, Migliacci Jocelyn, Ghossein Ronald, Shaha Ashok R

机构信息

Mercy Fitzgerald Hospital & Memorial Sloan Kettering Cancer Center, 1500 Lansdowne Avenue, Darby, PA, USA.

Memorial Sloan Kettering Cancer Center, Head and Neck Surgery, 1275 York Ave, New York, NY, USA.

出版信息

Am J Otolaryngol. 2016 Nov-Dec;37(6):534-537. doi: 10.1016/j.amjoto.2016.08.006. Epub 2016 Aug 18.

Abstract

BACKGROUND

de Quervain's thyroiditis is an inflammatory condition of the thyroid mostly treated medically, rarely requiring surgical treatment. We intend to review the surgical experience with de Quervain's thyroiditis at a tertiary cancer center over a period of 22years.

METHODS

A retrospective review of medical records from 1992 to 2014 at a tertiary cancer center was performed and all patients with a histopathological diagnosis of de Quervain's thyroiditis were included.

RESULTS

Ten patients with a histopathological diagnosis of de Quervain's thyroiditis were included in the study. One patient in the study presented with dysphagia due to the goiter. The remaining patients presented with thyroid nodules. None presented with typical symptoms of the disease. Seven of the ten patients that had been evaluated for a goiter at an outside facility underwent fine needle aspiration cytology. Of the seven patients, one patient was suspected to have medullary carcinoma of the thyroid, two had follicular neoplasia, and the others had indeterminate nodules. Eight of the ten patients underwent surgery for suspected malignancy, with eight receiving a total thyroidectomy and two patients getting a thyroid lobectomy with isthmusectomy. Two patients had an abnormally hard gland to palpate during surgery with the others not having any suspicious findings. Seven of the ten of the patients had lymph node sampling from level 6 and all were benign on final pathology. The mean duration of post-operative follow-up was 15months. There was no morbidity associated with surgery in any of these patients with eight of the ten patients requiring thyroid hormone replacement. None of the patients needed further neck surgery for thyroid disease.

CONCLUSION

de Quervain's thyroiditis is an inflammatory condition of the thyroid that is rarely treated surgically. However when presentation is atypical and the FNAC is inconclusive or is suspicious for a malignancy, patients receive surgery putting them at a risk for morbidity. Good clinical assessment with combined use of ultrasound with FNAC especially read by an experienced cytopathologist has the potential to reduce unnecessary operative intervention.

摘要

背景

亚急性甲状腺炎是一种甲状腺的炎症性疾病,大多采用药物治疗,很少需要手术治疗。我们打算回顾一家三级癌症中心22年来亚急性甲状腺炎的手术治疗经验。

方法

对一家三级癌症中心1992年至2014年的病历进行回顾性研究,纳入所有经组织病理学诊断为亚急性甲状腺炎的患者。

结果

本研究纳入了10例经组织病理学诊断为亚急性甲状腺炎的患者。研究中有1例患者因甲状腺肿大出现吞咽困难。其余患者表现为甲状腺结节。均无该病的典型症状。在外部机构接受甲状腺肿大评估的10例患者中,7例接受了细针穿刺细胞学检查。在这7例患者中,1例疑似甲状腺髓样癌,2例有滤泡性腺瘤形成,其余为不确定结节。10例患者中有8例因疑似恶性肿瘤接受手术,8例行全甲状腺切除术,2例行甲状腺叶切除术加峡部切除术。2例患者术中触诊腺体异常坚硬,其他患者未发现任何可疑情况。10例患者中有7例对6区进行了淋巴结采样,最终病理结果均为良性。术后平均随访时间为15个月。这些患者中无一例手术出现并发症,10例患者中有8例需要甲状腺激素替代治疗。所有患者均无需因甲状腺疾病再次进行颈部手术。

结论

亚急性甲状腺炎是一种甲状腺的炎症性疾病,很少进行手术治疗。然而,当临床表现不典型且细针穿刺细胞学检查结果不确定或怀疑为恶性肿瘤时,患者会接受手术,从而有发生并发症的风险。良好的临床评估,联合使用超声和细针穿刺细胞学检查,尤其是由经验丰富的细胞病理学家解读,有可能减少不必要的手术干预。

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